Official Gene Symbol | Other Aliases |
---|---|
PIK3CB | PIK3C1 |
Sequence Length (AA) | Molecular Weight (Da) |
---|---|
1070 | 122762 |
Protein Name |
---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
Sources | |
---|---|
UniProt PhosphoSitePlus ® GeneCards |
Human Protein Atlas |
10 | 20 | 30 | 40 | 50 |
MCFSFIMPPA | MADILDIWAV | DSQIASDGSI | PVDFLLPTGI | YIQLEVPREA |
60 | 70 | 80 | 90 | 100 |
TISYIKQMLW | KQVHNYPMFN | LLMDIDSYMF | ACVNQTAVYE | ELEDETRRLC |
110 | 120 | 130 | 140 | 150 |
DVRPFLPVLK | LVTRSCDPGE | KLDSKIGVLI | GKGLHEFDSL | KDPEVNEFRR |
160 | 170 | 180 | 190 | 200 |
KMRKFSEEKI | LSLVGLSWMD | WLKQTYPPEH | EPSIPENLED | KLYGGKLIVA |
210 | 220 | 230 | 240 | 250 |
VHFENCQDVF | SFQVSPNMNP | IKVNELAIQK | RLTIHGKEDE | VSPYDYVLQV |
260 | 270 | 280 | 290 | 300 |
SGRVEYVFGD | HPLIQFQYIR | NCVMNRALPH | FILVECCKIK | KMYEQEMIAI |
310 | 320 | 330 | 340 | 350 |
EAAINRNSSN | LPLPLPPKKT | RIISHVWENN | NPFQIVLVKG | NKLNTEETVK |
360 | 370 | 380 | 390 | 400 |
VHVRAGLFHG | TELLCKTIVS | SEVSGKNDHI | WNEPLEFDIN | ICDLPRMARL |
410 | 420 | 430 | 440 | 450 |
CFAVYAVLDK | VKTKKSTKTI | NPSKYQTIRK | AGKVHYPVAW | VNTMVFDFKG |
460 | 470 | 480 | 490 | 500 |
QLRTGDIILH | SWSSFPDELE | EMLNPMGTVQ | TNPYTENATA | LHVKFPENKK |
510 | 520 | 530 | 540 | 550 |
QPYYYPPFDK | IIEKAAEIAS | SDSANVSSRG | GKKFLPVLKE | ILDRDPLSQL |
560 | 570 | 580 | 590 | 600 |
CENEMDLIWT | LRQDCREIFP | QSLPKLLLSI | KWNKLEDVAQ | LQALLQIWPK |
610 | 620 | 630 | 640 | 650 |
LPPREALELL | DFNYPDQYVR | EYAVGCLRQM | SDEELSQYLL | QLVQVLKYEP |
660 | 670 | 680 | 690 | 700 |
FLDCALSRFL | LERALGNRRI | GQFLFWHLRS | EVHIPAVSVQ | FGVILEAYCR |
710 | 720 | 730 | 740 | 750 |
GSVGHMKVLS | KQVEALNKLK | TLNSLIKLNA | VKLNRAKGKE | AMHTCLKQSA |
760 | 770 | 780 | 790 | 800 |
YREALSDLQS | PLNPCVILSE | LYVEKCKYMD | SKMKPLWLVY | NNKVFGEDSV |
810 | 820 | 830 | 840 | 850 |
GVIFKNGDDL | RQDMLTLQML | RLMDLLWKEA | GLDLRMLPYG | CLATGDRSGL |
860 | 870 | 880 | 890 | 900 |
IEVVSTSETI | ADIQLNSSNV | AAAAAFNKDA | LLNWLKEYNS | GDDLDRAIEE |
910 | 920 | 930 | 940 | 950 |
FTLSCAGYCV | ASYVLGIGDR | HSDNIMVKKT | GQLFHIDFGH | ILGNFKSKFG |
960 | 970 | 980 | 990 | 1000 |
IKRERVPFIL | TYDFIHVIQQ | GKTGNTEKFG | RFRQCCEDAY | LILRRHGNLF |
1010 | 1020 | 1030 | 1040 | 1050 |
ITLFALMLTA | GLPELTSVKD | IQYLKDSLAL | GKSEEEALKQ | FKQKFDEALR |
1060 | 1070 | |||
ESWTTKVNWM | AHTVRKDYRS |
Data source: UniProt
Uniprot Database Entry PhosphoSitePlus ®
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Data source: Panorama
View Details (opens in a new window)
mTORC1-driven protein translation correlates with clinical benefit of capivasertib within a genetically preselected cohort of PIK3CA-altered tumours. Constance A Sobsey, Bjoern C Froehlich, Georgia Mitsa, Sahar Ibrahim, Robert Popp, Rene P Zahedi, Elza C de Bruin, Christoph H Borchers, Gerald Batist
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV![]() |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
b3 (1+) | 17.7 | 4.2 | 19.9 | 22.1 | 3.9 | 22.8 | 28.3 | 5.7 | 30.3 | 15 | 16 | 17 |
y10 (1+) | 16.4 | 7.5 | 6.9 | 20.2 | 6.6 | 5.6 | 26 | 10 | 8.9 | 15 | 16 | 17 |
y11 (1+) | 14.8 | 4.1 | 7.1 | 16.7 | 5.2 | 6.1 | 22.3 | 6.6 | 9.4 | 15 | 16 | 17 |
y3 (1+) | 13.6 | 7 | 6.6 | 18.8 | 8.3 | 6.5 | 23.2 | 10.9 | 9.3 | 15 | 16 | 17 |
y9 (1+) | 14.2 | 5.1 | 5.5 | 16.4 | 8.4 | 5 | 21.7 | 9.8 | 7.4 | 15 | 16 | 17 |
sum | 13 | 3 | 5.2 | 16.1 | 2.1 | 4.1 | 20.7 | 3.7 | 6.6 | 15 | 16 | 17 |
Data source: Panorama
Fragment ion / Transition | control_intra_CV | actual_temp_intra_CV | frozen_intra_CV | FTx1_intra_CV | FTx2_intra_CV |
---|---|---|---|---|---|
b3 (1+) | 4.7 | 5.4 | 3.5 | 3.1 | 8.9 |
y10 (1+) | 4.6 | 2.3 | 5.3 | 4.6 | 2.1 |
y11 (1+) | 7.3 | 8 | 6.9 | 8.1 | 17.6 |
y3 (1+) | 10.6 | 7.4 | 5.9 | 13.3 | 7 |
y9 (1+) | 5.5 | 9.2 | 6 | 9.2 | 12.9 |
sum | 2 | 1.4 | 2.3 | 3.9 | 5.2 |
Fragment ion / Transition | all_intra_CV | all_inter_CV |
---|---|---|
b3 (1+) | 5.2 | 5 |
y10 (1+) | 3.5 | 4.1 |
y11 (1+) | 9.3 | 8.8 |
y3 (1+) | 8.6 | 9.4 |
y9 (1+) | 8.7 | 7.3 |
sum | 2.7 | 3 |
Data source: Panorama
Fragment ion / Transition | intra_CV | inter_CV | total_CV |
---|---|---|---|
b3 (1+) | 7.8 | 10.3 | 12.9 |
y10 (1+) | 9.8 | 8.8 | 13.2 |
y11 (1+) | 7.7 | 7.9 | 11 |
y3 (1+) | 5.4 | 19.6 | 20.3 |
y9 (1+) | 4.4 | 20.9 | 21.4 |
sum | 0.3 | 5.3 | 5.3 |
Data source: Panorama
View Details (opens in a new window)
mTORC1-driven protein translation correlates with clinical benefit of capivasertib within a genetically preselected cohort of PIK3CA-altered tumours. Constance A Sobsey, Bjoern C Froehlich, Georgia Mitsa, Sahar Ibrahim, Robert Popp, Rene P Zahedi, Elza C de Bruin, Christoph H Borchers, Gerald Batist
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV![]() |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y2 (1+) | 8.6 | 4.4 | 6.1 | 10.7 | 3.5 | 5 | 13.7 | 5.6 | 7.9 | 16 | 16 | 17 |
y3 (1+) | 8.8 | 3.3 | 5.8 | 10 | 3.5 | 5.5 | 13.3 | 4.8 | 8 | 16 | 16 | 17 |
y5 (1+) | 10 | 5.5 | 1.8 | 10.2 | 7.1 | 3.7 | 14.3 | 9 | 4.1 | 16 | 16 | 17 |
y4 (2+) | 52.9 | 11.2 | 4 | 51.9 | 12.2 | 4 | 74.1 | 16.6 | 5.7 | 16 | 16 | 17 |
y5 (2+) | 21 | 4.8 | 4.8 | 20.3 | 4.7 | 4 | 29.2 | 6.7 | 6.2 | 16 | 16 | 17 |
sum | 5.5 | 2.1 | 2.8 | 6.2 | 1.9 | 3.2 | 8.3 | 2.8 | 4.3 | 16 | 16 | 17 |
Data source: Panorama
Fragment ion / Transition | control_intra_CV | actual_temp_intra_CV | frozen_intra_CV | FTx1_intra_CV | FTx2_intra_CV |
---|---|---|---|---|---|
Fragment ion / Transition | all_intra_CV | all_inter_CV |
---|---|---|
Data source: Panorama
Fragment ion / Transition | intra_CV | inter_CV | total_CV |
---|---|---|---|
y2 (1+) | 2.7 | 46.5 | 46.6 |
y3 (1+) | 20.1 | 34.9 | 40.3 |
y5 (1+) | 6.6 | 18.9 | 20 |
y4 (2+) | 15.5 | 49.8 | 52.2 |
y5 (2+) | 44.9 | 67.2 | 80.8 |
sum | 9.9 | 18.6 | 21.1 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV![]() |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y4 (1+) | 5.3 | 3.4 | 4.1 | 5.4 | 7.4 | 7 | 7.6 | 8.1 | 8.1 | 15 | 15 | 15 |
y5 (1+) | 5.5 | 3.5 | 4.9 | 5 | 7.7 | 6.9 | 7.4 | 8.5 | 8.5 | 15 | 15 | 15 |
y3 (1+) | 4.4 | 2.9 | 4.4 | 4.8 | 6.4 | 6.3 | 6.5 | 7 | 7.7 | 15 | 15 | 15 |
sum | 4.4 | 3.2 | 4.5 | 4.5 | 7.2 | 6.7 | 6.3 | 7.9 | 8.1 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV![]() |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y7 (1+) | 20.6 | 6.1 | 9.7 | 32 | 9.2 | 21.6 | 38.1 | 11 | 23.7 | 15 | 15 | 15 |
y6 (1+) | 15.4 | 4.7 | 9 | 25.5 | 10.8 | 18.4 | 29.8 | 11.8 | 20.5 | 15 | 15 | 15 |
y9 (1+) | 13.3 | 3.9 | 4.9 | 20.1 | 7.5 | 17.3 | 24.1 | 8.5 | 18 | 15 | 15 | 15 |
sum | 13.3 | 3 | 6.9 | 22.8 | 7.4 | 18.2 | 26.4 | 8 | 19.5 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV![]() |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y5 (1+) | 14.4 | 5 | 6.5 | 16.8 | 8.7 | 7.6 | 22.1 | 10 | 10 | 15 | 15 | 15 |
y3 (1+) | 10.4 | 4.5 | 5.4 | 12.7 | 9 | 8.2 | 16.4 | 10.1 | 9.8 | 15 | 15 | 15 |
y10 (1+) | 13 | 5.8 | 6.8 | 16 | 11 | 8.4 | 20.6 | 12.4 | 10.8 | 15 | 15 | 15 |
sum | 11.9 | 5.3 | 6.2 | 14.5 | 10 | 8 | 18.8 | 11.3 | 10.1 | 15 | 15 | 15 |
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