Official Gene Symbol | Other Aliases |
---|---|
MDC1 | KIAA0170, NFBD1 |
Sequence Length (AA) | Molecular Weight (Da) |
---|---|
2089 | 226666 |
Protein Name |
---|
Mediator of DNA damage checkpoint protein 1 |
Sources | |
---|---|
UniProt PhosphoSitePlus ® GeneCards |
Human Protein Atlas |
10 | 20 | 30 | 40 | 50 |
MEDTQAIDWD | VEEEEETEQS | SESLRCNVEP | VGRLHIFSGA | HGPEKDFPLH |
60 | 70 | 80 | 90 | 100 |
LGKNVVGRMP | DCSVALPFPS | ISKQHAEIEI | LAWDKAPILR | DCGSLNGTQI |
110 | 120 | 130 | 140 | 150 |
LRPPKVLSPG | VSHRLRDQEL | ILFADLLCQY | HRLDVSLPFV | SRGPLTVEET |
160 | 170 | 180 | 190 | 200 |
PRVQGETQPQ | RLLLAEDSEE | EVDFLSERRM | VKKSRTTSSS | VIVPESDEEG |
210 | 220 | 230 | 240 | 250 |
HSPVLGGLGP | PFAFNLNSDT | DVEEGQQPAT | EEASSAARRG | ATVEAKQSEA |
260 | 270 | 280 | 290 | 300 |
EVVTEIQLEK | DQPLVKERDN | DTKVKRGAGN | GVVPAGVILE | RSQPPGEDSD |
310 | 320 | 330 | 340 | 350 |
TDVDDDSRPP | GRPAEVHLER | AQPFGFIDSD | TDAEEERIPA | TPVVIPMKKR |
360 | 370 | 380 | 390 | 400 |
KIFHGVGTRG | PGAPGLAHLQ | ESQAGSDTDV | EEGKAPQAVP | LEKSQASMVI |
410 | 420 | 430 | 440 | 450 |
NSDTDDEEEV | SAALTLAHLK | ESQPAIWNRD | AEEDMPQRVV | LLQRSQTTTE |
460 | 470 | 480 | 490 | 500 |
RDSDTDVEEE | ELPVENREAV | LKDHTKIRAL | VRAHSEKDQP | PFGDSDDSVE |
510 | 520 | 530 | 540 | 550 |
ADKSSPGIHL | ERSQASTTVD | INTQVEKEVP | PGSAIIHIKK | HQVSVEGTNQ |
560 | 570 | 580 | 590 | 600 |
TDVKAVGGPA | KLLVVSLEEA | WPLHGDCETD | AEEGTSLTAS | VVADVRKSQL |
610 | 620 | 630 | 640 | 650 |
PAEGDAGAEW | AAAVLKQERA | HEVGAQGGPP | VAQVEQDLPI | SRENLTDLVV |
660 | 670 | 680 | 690 | 700 |
DTDTLGESTQ | PQREGAQVPT | GREREQHVGG | TKDSEDNYGD | SEDLDLQATQ |
710 | 720 | 730 | 740 | 750 |
CFLENQGLEA | VQSMEDEPTQ | AFMLTPPQEL | GPSHCSFQTT | GTLDEPWEVL |
760 | 770 | 780 | 790 | 800 |
ATQPFCLRES | EDSETQPFDT | HLEAYGPCLS | PPRAIPGDQH | PESPVHTEPM |
810 | 820 | 830 | 840 | 850 |
GIQGRGRQTV | DKVMGIPKET | AERVGPERGP | LERETEKLLP | ERQTDVTGEE |
860 | 870 | 880 | 890 | 900 |
ELTKGKQDRE | QKQLLARDTQ | RQESDKNGES | ASPERDRESL | KVEIETSEEI |
910 | 920 | 930 | 940 | 950 |
QEKQVQKQTL | PSKAFEREVE | RPVANRECDP | AELEEKVPKV | ILERDTQRGE |
960 | 970 | 980 | 990 | 1000 |
PEGGSQDQKG | QASSPTPEPG | VGAGDLPGPT | SAPVPSGSQS | GGRGSPVSPR |
1010 | 1020 | 1030 | 1040 | 1050 |
RHQKGLLNCK | MPPAEKASRI | RAAEKVSRGD | QESPDACLPP | TVPEAPAPPQ |
1060 | 1070 | 1080 | 1090 | 1100 |
KPLNSQSQKH | LAPPPLLSPL | LPSIKPTVRK | TRQDGSQEAP | EAPLSSELEP |
1110 | 1120 | 1130 | 1140 | 1150 |
FHPKPKIRTR | KSSRMTPFPA | TSAAPEPHPS | TSTAQPVTPK | PTSQATRSRT |
1160 | 1170 | 1180 | 1190 | 1200 |
NRSSVKTPEP | VVPTAPELQP | STSTDQPVTS | EPTSQVTRGR | KSRSSVKTPE |
1210 | 1220 | 1230 | 1240 | 1250 |
TVVPTALELQ | PSTSTDRPVT | SEPTSQATRG | RKNRSSVKTP | EPVVPTAPEL |
1260 | 1270 | 1280 | 1290 | 1300 |
QPSTSTDQPV | TSEPTYQATR | GRKNRSSVKT | PEPVVPTAPE | LRPSTSTDRP |
1310 | 1320 | 1330 | 1340 | 1350 |
VTPKPTSRTT | RSRTNMSSVK | TPETVVPTAP | ELQISTSTDQ | PVTPKPTSRT |
1360 | 1370 | 1380 | 1390 | 1400 |
TRSRTNMSSV | KNPESTVPIA | PELPPSTSTE | QPVTPEPTSR | ATRGRKNRSS |
1410 | 1420 | 1430 | 1440 | 1450 |
GKTPETLVPT | APKLEPSTST | DQPVTPEPTS | QATRGRTNRS | SVKTPETVVP |
1460 | 1470 | 1480 | 1490 | 1500 |
TAPELQPSTS | TDQPVTPEPT | SQATRGRTDR | SSVKTPETVV | PTAPELQASA |
1510 | 1520 | 1530 | 1540 | 1550 |
STDQPVTSEP | TSRTTRGRKN | RSSVKTPETV | VPAAPELQPS | TSTDQPVTPE |
1560 | 1570 | 1580 | 1590 | 1600 |
PTSRATRGRT | NRSSVKTPES | IVPIAPELQP | STSRNQLVTP | EPTSRATRCR |
1610 | 1620 | 1630 | 1640 | 1650 |
TNRSSVKTPE | PVVPTAPEPH | PTTSTDQPVT | PKLTSRATRR | KTNRSSVKTP |
1660 | 1670 | 1680 | 1690 | 1700 |
KPVEPAASDL | EPFTPTDQSV | TPEAIAQGGQ | SKTLRSSTVR | AMPVPTTPEF |
1710 | 1720 | 1730 | 1740 | 1750 |
QSPVTTDQPI | SPEPITQPSC | IKRQRAAGNP | GSLAAPIDHK | PCSAPLEPKS |
1760 | 1770 | 1780 | 1790 | 1800 |
QASRNQRWGA | VRAAESLTAI | PEPASPQLLE | TPIHASQIQK | VEPAGRSRFT |
1810 | 1820 | 1830 | 1840 | 1850 |
PELQPKASQS | RKRSLATMDS | PPHQKQPQRG | EVSQKTVIIK | EEEEDTAEKP |
1860 | 1870 | 1880 | 1890 | 1900 |
GKEEDVVTPK | PGKRKRDQAE | EEPNRIPSRS | LRRTKLNQES | TAPKVLFTGV |
1910 | 1920 | 1930 | 1940 | 1950 |
VDARGERAVL | ALGGSLAGSA | AEASHLVTDR | IRRTVKFLCA | LGRGIPILSL |
1960 | 1970 | 1980 | 1990 | 2000 |
DWLHQSRKAG | FFLPPDEYVV | TDPEQEKNFG | FSLQDALSRA | RERRLLEGYE |
2010 | 2020 | 2030 | 2040 | 2050 |
IYVTPGVQPP | PPQMGEIISC | CGGTYLPSMP | RSYKPQRVVI | TCPQDFPHCS |
2060 | 2070 | 2080 | 2089 | |
IPLRVGLPLL | SPEFLLTGVL | KQEAKPEAFV | LSPLEMSST |
Data source: UniProt
Uniprot Database Entry PhosphoSitePlus ®
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Data source: Panorama
View Details (opens in a new window)
Kennedy JJ, Yan P, Zhao L, Ivey RG, Voytovich U, Moore HD, Lin C, Pogosova-Agadjanyan EL, Stirewalt DL, Reding KW, Whiteaker JR, Paulovich AG. Immobilized metal affinity chromatography coupled to multiple reaction monitoring enables reproducible quantification of phospho-signaling. Molecular and Cellular Proteomics. mcp.O115.054940
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y14 (2+) | 34.2 | 29.8 | 23.1 | 35.8 | 32.9 | 22 | 49.5 | 44.4 | 31.9 | 15 | 23 | 15 |
y15 (2+) | 33.4 | 13.3 | 18.4 | 29.2 | 19.7 | 21.4 | 44.4 | 23.8 | 28.2 | 15 | 23 | 15 |
y5 (1+) | 67.5 | 44.9 | 55.4 | 55.7 | 38.9 | 71.6 | 87.5 | 59.4 | 90.5 | 15 | 23 | 15 |
sum | 32.2 | 9.7 | 7.7 | 27.2 | 19 | 12.2 | 42.2 | 21.3 | 14.4 | 15 | 23 | 15 |
Data source: Panorama
View Details (opens in a new window)
A Multiplexed Mass Spectrometry-Based Assay for Robust Quantification of Phosphosignaling in Response to DNA Damage. Whiteaker JR, Zhao L, Saul R, Kaczmarczyk JA, Schoenherr RM, Moore HD, Jones-Weinert C, Ivey RG, Lin C, Hiltke T, Reding KW, Whiteley G, Wang P, Paulovich AG. Radiat Res. 2018 Feb 23. doi: 10.1667/RR14963.1. [Epub ahead of print]
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y10 (1+) | 22.3 | 9.3 | 12.2 | 52.4 | 16.8 | 13.1 | 56.9 | 19.2 | 17.9 | 15 | 15 | 15 |
y7 (1+) | 26.6 | 19.9 | 18 | 52.9 | 18.5 | 19.8 | 59.2 | 27.2 | 26.8 | 15 | 15 | 15 |
y9 (1+) | 18.4 | 19.7 | 19.9 | 39.3 | 19.8 | 31.4 | 43.4 | 27.9 | 37.2 | 15 | 15 | 15 |
sum | 13.8 | 9.3 | 13.2 | 45.7 | 14 | 14.7 | 47.7 | 16.8 | 19.8 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
A Multiplexed Mass Spectrometry-Based Assay for Robust Quantification of Phosphosignaling in Response to DNA Damage. Whiteaker JR, Zhao L, Saul R, Kaczmarczyk JA, Schoenherr RM, Moore HD, Jones-Weinert C, Ivey RG, Lin C, Hiltke T, Reding KW, Whiteley G, Wang P, Paulovich AG. Radiat Res. 2018 Feb 23. doi: 10.1667/RR14963.1. [Epub ahead of print]
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y9 (1+) | 32.6 | 10.9 | 12.6 | 67.5 | 19.2 | 21.8 | 75 | 22.1 | 25.2 | 15 | 15 | 15 |
y5 (1+) | 30.2 | 12.2 | 17.6 | 70.6 | 20.6 | 16.4 | 76.8 | 23.9 | 24.1 | 15 | 15 | 15 |
y14 (2+) | 21.7 | 14.5 | 16.1 | 59.4 | 25.9 | 14.7 | 63.2 | 29.7 | 21.8 | 15 | 15 | 15 |
y15 (2+) | 18.2 | 5.7 | 11 | 63.3 | 15.5 | 14.3 | 65.9 | 16.5 | 18 | 15 | 15 | 15 |
sum | 15.6 | 5.4 | 8.8 | 62.7 | 16.3 | 13.5 | 64.6 | 17.2 | 16.1 | 15 | 15 | 15 |
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