Official Gene Symbol | Other Aliases |
---|---|
TOPBP1 | KIAA0259 |
Sequence Length (AA) | Molecular Weight (Da) |
---|---|
1522 | 170679 |
Protein Name |
---|
DNA topoisomerase 2-binding protein 1 |
Sources | |
---|---|
UniProt PhosphoSitePlus ® GeneCards |
Human Protein Atlas |
10 | 20 | 30 | 40 | 50 |
MSRNDKEPFF | VKFLKSSDNS | KCFFKALESI | KEFQSEEYLQ | IITEEEALKI |
60 | 70 | 80 | 90 | 100 |
KENDRSLYIC | DPFSGVVFDH | LKKLGCRIVG | PQVVIFCMHH | QRCVPRAEHP |
110 | 120 | 130 | 140 | 150 |
VYNMVMSDVT | ISCTSLEKEK | REEVHKYVQM | MGGRVYRDLN | VSVTHLIAGE |
160 | 170 | 180 | 190 | 200 |
VGSKKYLVAA | NLKKPILLPS | WIKTLWEKSQ | EKKITRYTDI | NMEDFKCPIF |
210 | 220 | 230 | 240 | 250 |
LGCIICVTGL | CGLDRKEVQQ | LTVKHGGQYM | GQLKMNECTH | LIVQEPKGQK |
260 | 270 | 280 | 290 | 300 |
YECAKRWNVH | CVTTQWFFDS | IEKGFCQDES | IYKTEPRPEA | KTMPNSSTPT |
310 | 320 | 330 | 340 | 350 |
SQINTIDSRT | LSDVSNISNI | NASCVSESIC | NSLNSKLEPT | LENLENLDVS |
360 | 370 | 380 | 390 | 400 |
AFQAPEDLLD | GCRIYLCGFS | GRKLDKLRRL | INSGGGVRFN | QLNEDVTHVI |
410 | 420 | 430 | 440 | 450 |
VGDYDDELKQ | FWNKSAHRPH | VVGAKWLLEC | FSKGYMLSEE | PYIHANYQPV |
460 | 470 | 480 | 490 | 500 |
EIPVSHKPES | KAALLKKKNS | SFSKKDFAPS | EKHEQADEDL | LSQYENGSST |
510 | 520 | 530 | 540 | 550 |
VVEAKTSEAR | PFNDSTHAEP | LNDSTHISLQ | EENQSSVSHC | VPDVSTITEE |
560 | 570 | 580 | 590 | 600 |
GLFSQKSFLV | LGFSNENESN | IANIIKENAG | KIMSLLSRTV | ADYAVVPLLG |
610 | 620 | 630 | 640 | 650 |
CEVEATVGEV | VTNTWLVTCI | DYQTLFDPKS | NPLFTPVPVM | TGMTPLEDCV |
660 | 670 | 680 | 690 | 700 |
ISFSQCAGAE | KESLTFLANL | LGASVQEYFV | RKSNAKKGMF | ASTHLILKER |
710 | 720 | 730 | 740 | 750 |
GGSKYEAAKK | WNLPAVTIAW | LLETARTGKR | ADESHFLIEN | STKEERSLET |
760 | 770 | 780 | 790 | 800 |
EITNGINLNS | DTAEHPGTRL | QTHRKTVVTP | LDMNRFQSKA | FRAVVSQHAR |
810 | 820 | 830 | 840 | 850 |
QVAASPAVGQ | PLQKEPSLHL | DTPSKFLSKD | KLFKPSFDVK | DALAALETPG |
860 | 870 | 880 | 890 | 900 |
RPSQQKRKPS | TPLSEVIVKN | LQLALANSSR | NAVALSASPQ | LKEAQSEKEE |
910 | 920 | 930 | 940 | 950 |
APKPLHKVVV | CVSKKLSKKQ | SELNGIAASL | GADYRWSFDE | TVTHFIYQGR |
960 | 970 | 980 | 990 | 1000 |
PNDTNREYKS | VKERGVHIVS | EHWLLDCAQE | CKHLPESLYP | HTYNPKMSLD |
1010 | 1020 | 1030 | 1040 | 1050 |
ISAVQDGRLC | NSRLLSAVSS | TKDDEPDPLI | LEENDVDNMA | TNNKESAPSN |
1060 | 1070 | 1080 | 1090 | 1100 |
GSGKNDSKGV | LTQTLEMREN | FQKQLQEIMS | ATSIVKPQGQ | RTSLSRSGCN |
1110 | 1120 | 1130 | 1140 | 1150 |
SASSTPDSTR | SARSGRSRVL | EALRQSRQTV | PDVNTEPSQN | EQIIWDDPTA |
1160 | 1170 | 1180 | 1190 | 1200 |
REERARLASN | LQWPSCPTQY | SELQVDIQNL | EDSPFQKPLH | DSEIAKQAVC |
1210 | 1220 | 1230 | 1240 | 1250 |
DPGNIRVTEA | PKHPISEELE | TPIKDSHLIP | TPQAPSIAFP | LANPPVAPHP |
1260 | 1270 | 1280 | 1290 | 1300 |
REKIITIEET | HEELKKQYIF | QLSSLNPQER | IDYCHLIEKL | GGLVIEKQCF |
1310 | 1320 | 1330 | 1340 | 1350 |
DPTCTHIVVG | HPLRNEKYLA | SVAAGKWVLH | RSYLEACRTA | GHFVQEEDYE |
1360 | 1370 | 1380 | 1390 | 1400 |
WGSSSILDVL | TGINVQQRRL | ALAAMRWRKK | IQQRQESGIV | EGAFSGWKVI |
1410 | 1420 | 1430 | 1440 | 1450 |
LHVDQSREAG | FKRLLQSGGA | KVLPGHSVPL | FKEATHLFSD | LNKLKPDDSG |
1460 | 1470 | 1480 | 1490 | 1500 |
VNIAEAAAQN | VYCLRTEYIA | DYLMQESPPH | VENYCLPEAI | SFIQNNKELG |
1510 | 1520 | 1522 | ||
TGLSQKRKAP | TEKNKIKRPR | VH |
Data source: UniProt
Uniprot Database Entry PhosphoSitePlus ®
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Data source: Panorama
View Details (opens in a new window)
A Multiplexed Mass Spectrometry-Based Assay for Robust Quantification of Phosphosignaling in Response to DNA Damage. Whiteaker JR, Zhao L, Saul R, Kaczmarczyk JA, Schoenherr RM, Moore HD, Jones-Weinert C, Ivey RG, Lin C, Hiltke T, Reding KW, Whiteley G, Wang P, Paulovich AG. Radiat Res. 2018 Feb 23. doi: 10.1667/RR14963.1. [Epub ahead of print]
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y6 (1+) | 41.3 | 23.2 | 18.3 | 52.6 | 22.2 | 18.7 | 66.9 | 32.1 | 26.2 | 15 | 15 | 15 |
y8 (1+) | 20.1 | 43.5 | 18.3 | 60.6 | 32.7 | 29.3 | 63.8 | 54.4 | 34.5 | 15 | 15 | 15 |
y7 (1+) | 64.3 | 10.3 | 16.5 | 84.4 | 12.4 | 17.6 | 106.1 | 16.1 | 24.1 | 15 | 15 | 15 |
sum | 30.6 | 13.1 | 11.9 | 63.5 | 11.1 | 15 | 70.5 | 17.2 | 19.1 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
A Multiplexed Mass Spectrometry-Based Assay for Robust Quantification of Phosphosignaling in Response to DNA Damage. Whiteaker JR, Zhao L, Saul R, Kaczmarczyk JA, Schoenherr RM, Moore HD, Jones-Weinert C, Ivey RG, Lin C, Hiltke T, Reding KW, Whiteley G, Wang P, Paulovich AG. Radiat Res. 2018 Feb 23. doi: 10.1667/RR14963.1. [Epub ahead of print]
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y5 (1+) | 28 | 33.1 | 25.3 | 70.2 | 57 | 41.5 | 75.6 | 65.9 | 48.6 | 15 | 15 | 15 |
y7-98 (1+) | 17.7 | 29 | 29.2 | 36.4 | 52.1 | 39.7 | 40.5 | 59.6 | 49.3 | 15 | 15 | 15 |
y6 (1+) | 27.7 | 25.3 | 21.7 | 37.2 | 39.5 | 31.6 | 46.4 | 46.9 | 38.3 | 15 | 15 | 15 |
y7 (1+) | 22.2 | 32.3 | 24.6 | 34.1 | 48.8 | 36.6 | 40.7 | 58.5 | 44.1 | 15 | 15 | 15 |
y8 (1+) | 30.2 | 34.6 | 30.5 | 49.7 | 55.5 | 38.1 | 58.2 | 65.4 | 48.8 | 15 | 15 | 15 |
y8-98 (1+) | 32 | 27.4 | 30.2 | 28.6 | 44.1 | 38.1 | 42.9 | 51.9 | 48.6 | 15 | 15 | 15 |
sum | 14.1 | 22.6 | 22.2 | 42.2 | 47.5 | 36.7 | 44.5 | 52.6 | 42.9 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Kennedy JJ, Yan P, Zhao L, Ivey RG, Voytovich U, Moore HD, Lin C, Pogosova-Agadjanyan EL, Stirewalt DL, Reding KW, Whiteaker JR, Paulovich AG. Immobilized metal affinity chromatography coupled to multiple reaction monitoring enables reproducible quantification of phospho-signaling. Molecular and Cellular Proteomics. mcp.O115.054940
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y4 (1+) | 15.9 | 10.4 | 7.9 | 30.1 | 10.8 | 10.7 | 34 | 15 | 13.3 | 15 | 24 | 15 |
y7 (1+) | 20.8 | 9 | 9.4 | 17.5 | 9 | 11.6 | 27.2 | 12.7 | 14.9 | 15 | 24 | 15 |
y9 (1+) | 20.7 | 6.4 | 11.9 | 25.6 | 7.6 | 12.2 | 32.9 | 9.9 | 17 | 15 | 24 | 15 |
sum | 16 | 6.5 | 9.3 | 21.5 | 7.3 | 10.1 | 26.8 | 9.8 | 13.7 | 15 | 24 | 15 |
Data source: Panorama
View Details (opens in a new window)
A Multiplexed Mass Spectrometry-Based Assay for Robust Quantification of Phosphosignaling in Response to DNA Damage. Whiteaker JR, Zhao L, Saul R, Kaczmarczyk JA, Schoenherr RM, Moore HD, Jones-Weinert C, Ivey RG, Lin C, Hiltke T, Reding KW, Whiteley G, Wang P, Paulovich AG. Radiat Res. 2018 Feb 23. doi: 10.1667/RR14963.1. [Epub ahead of print]
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y5 (1+) | 86.4 | 50.6 | 30.8 | 138.1 | 76.1 | 38.6 | 162.9 | 91.4 | 49.4 | 15 | 15 | 15 |
y4 (1+) | 54.9 | 45.5 | 36.5 | 117.7 | 60.2 | 43.5 | 129.9 | 75.5 | 56.8 | 15 | 15 | 15 |
y15 (2+) | 32.9 | 31.3 | 38.5 | 86.7 | 53.1 | 39.5 | 92.7 | 61.6 | 55.2 | 15 | 15 | 15 |
y8 (1+) | 33.1 | 39.5 | 29.6 | 61.3 | 50.3 | 38.6 | 69.7 | 64 | 48.6 | 15 | 15 | 15 |
y7 (1+) | 53.5 | 25 | 28.6 | 99 | 33.8 | 45.1 | 112.5 | 42 | 53.4 | 15 | 15 | 15 |
y6 (1+) | 36.9 | 20.2 | 39 | 82.3 | 50.1 | 55.2 | 90.2 | 54 | 67.6 | 15 | 15 | 15 |
y9 (1+) | 69.6 | 33.9 | 30.7 | 104.9 | 52.9 | 34.1 | 125.9 | 62.8 | 45.9 | 15 | 15 | 15 |
sum | 19.8 | 18.9 | 24.4 | 70 | 29.2 | 37.3 | 72.7 | 34.8 | 44.6 | 15 | 15 | 15 |
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