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Please include the following statement when referencing the CPTAC Assay Portal
We would like to acknowledge the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) Assay Portal (assays.cancer.gov) for developing assays and establishing criteria for the assays described in this publication.

FCGBP

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Available Assays

Overview Data source: UniProt

Official Gene Symbol Other Aliases
FCGBP N/A
Sequence Length (AA) Molecular Weight (Da)
5405 572017
Protein Name
IgGFc-binding protein
Sources
UniProt
PhosphoSitePlus ®
GeneCards 		Human Protein Atlas

Protein Sequence hover to view complete sequence

10 20 30 40 50
MGALWSWWIL WAGATLLWGL TQEASVDLKN TGREEFLTAF LQNYQLAYSK
60 70 80 90 100
AYPRLLISSL SESPASVSIL SQADNTSKKV TVRPGESVMV NISAKAEMIG
110 120 130 140 150
SKIFQHAVVI HSDYAISVQA LNAKPDTAEL TLLRPIQALG TEYFVLTPPG
160 170 180 190 200
TSARNVKEFA VVAGAAGASV SVTLKGSVTF NGKFYPAGDV LRVTLQPYNV
210 220 230 240 250
AQLQSSVDLS GSKVTASSPV AVLSGHSCAQ KHTTCNHVVE QLLPTSAWGT
260 270 280 290 300
HYVVPTLASQ SRYDLAFVVA SQATKLTYNH GGITGSRGLQ AGDVVEFEVR
310 320 330 340 350
PSWPLYLSAN VGIQVLLFGT GAIRNEVTYD PYLVLIPDVA AYCPAYVVKS
360 370 380 390 400
VPGCEGVALV VAQTKAISGL TIDGHAVGAK LTWEAVPGSE FSYAEVELGT
410 420 430 440 450
ADMIHTAEAT TNLGLLTFGL AKAIGYATAA DCGRTVLSPV EPSCEGMQCA
460 470 480 490 500
AGQRCQVVGG KAGCVAESTA VCRAQGDPHY TTFDGRRYDM MGTCSYTMVE
510 520 530 540 550
LCSEDDTLPA FSVEAKNEHR GSRRVSYVGL VTVRAYSHSV SLTRGEVGFV
560 570 580 590 600
LVDNQRSRLP VSLSEGRLRV YQSGPRAVVE LVFGLVVTYD WDCQLALSLP
610 620 630 640 650
ARFQDQVCGL CGNYNGDPAD DFLTPDGALA PDAVEFASSW KLDDGDYLCE
660 670 680 690 700
DGCQNNCPAC TPGQAQHYEG DRLCGMLTKL DGPFAVCHDT LDPRPFLEQC
710 720 730 740 750
VYDLCVVGGE RLSLCRGLSA YAQACLELGI SVGDWRSPAN CPLSCPANSR
760 770 780 790 800
YELCGPACPT SCNGAAAPSN CSGRPCVEGC VCLPGFVASG GACVPASSCG
810 820 830 840 850
CTFQGLQLAP GQEVWADELC QRRCTCNGAT HQVTCRDKQS CPAGERCSVQ
860 870 880 890 900
NGLLGCYPDR FGTCQGSGDP HYVSFDGRRF DFMGTCTYLL VGSCGQNAAL
910 920 930 940 950
PAFRVLVENE HRGSQTVSYT RAVRVEARGV KVAVRREYPG QVLVDDVLQY
960 970 980 990 1000
LPFQAADGQV QVFRQGRDAV VRTDFGLTVT YDWNARVTAK VPSSYAEALC
1010 1020 1030 1040 1050
GLCGNFNGDP ADDLALRGGG QAANALAFGN SWQEETRPGC GATEPGDCPK
1060 1070 1080 1090 1100
LDSLVAQQLQ SKNECGILAD PKGPFRECHS KLDPQGAVRD CVYDRCLLPG
1110 1120 1130 1140 1150
QSGPLCDALA TYAAACQAAG ATVHPWRSEE LCPLSCPPHS HYEACSYGCP
1160 1170 1180 1190 1200
LSCGDLPVPG GCGSECHEGC VCDEGFALSG ESCLPLASCG CVHQGTYHPP
1210 1220 1230 1240 1250
GQTFYPGPGC DSLCHCQEGG LVSCESSSCG PHEACQPSGG SLGCVAVGSS
1260 1270 1280 1290 1300
TCQASGDPHY TTFDGRRFDF MGTCVYVLAQ TCGTRPGLHR FAVLQENVAW
1310 1320 1330 1340 1350
GNGRVSVTRV ITVQVANFTL RLEQRQWKVT VNGVDMKLPV VLANGQIRAS
1360 1370 1380 1390 1400
QHGSDVVIET DFGLRVAYDL VYYVRVTVPG NYYQQMCGLC GNYNGDPKDD
1410 1420 1430 1440 1450
FQKPNGSQAG NANEFGNSWE EVVPDSPCLP PTPCPPGSED CIPSHKCPPE
1460 1470 1480 1490 1500
LEKKYQKEEF CGLLSSPTGP LSSCHKLVDP QGPLKDCIFD LCLGGGNLSI
1510 1520 1530 1540 1550
LCSNIHAYVS ACQAAGGHVE PWRTETFCPM ECPPNSHYEL CADTCSLGCS
1560 1570 1580 1590 1600
ALSAPPQCQD GCAEGCQCDS GFLYNGQACV PIQQCGCYHN GVYYEPEQTV
1610 1620 1630 1640 1650
LIDNCRQQCT CHAGKGMVCQ EHSCKPGQVC QPSGGILSCV TKDPCHGVTC
1660 1670 1680 1690 1700
RPQETCKEQG GQGVCLPNYE ATCWLWGDPH YHSFDGRKFD FQGTCNYVLA
1710 1720 1730 1740 1750
TTGCPGVSTQ GLTPFTVTTK NQNRGNPAVS YVRVVTVAAL GTNISIHKDE
1760 1770 1780 1790 1800
IGKVRVNGVL TALPVSVADG RISVTQGASK ALLVADFGLQ VSYDWNWRVD
1810 1820 1830 1840 1850
VTLPSSYHGA VCGLCGNMDR NPNNDQVFPN GTLAPSIPIW GGSWRAPGWD
1860 1870 1880 1890 1900
PLCWDECRGS CPTCPEDRLE QYEGPGFCGP LAPGTGGPFT TCHAHVPPES
1910 1920 1930 1940 1950
FFKGCVLDVC MGGGDRDILC KALASYVAAC QAAGVVIEDW RAQVGCEITC
1960 1970 1980 1990 2000
PENSHYEVCG SPCPASCPSP APLTTPAVCE GPCVEGCQCD AGFVLSADRC
2010 2020 2030 2040 2050
VPLNNGCGCW ANGTYHEAGS EFWADGTCSQ WCRCGPGGGS LVCTPASCGL
2060 2070 2080 2090 2100
GEVCGLLPSG QHGCQPVSTA ECQAWGDPHY VTLDGHRFNF QGTCEYLLSA
2110 2120 2130 2140 2150
PCHGPPLGAE NFTVTVANEH RGSQAVSYTR SVTLQIYNHS LTLSARWPRK
2160 2170 2180 2190 2200
LQVDGVFVTL PFQLDSLLHA HLSGADVVVT TTSGLSLAFD GDSFVRLRVP
2210 2220 2230 2240 2250
AAYAGSLCGL CGNYNQDPAD DLKAVGGKPA GWQVGGAQGC GECVSKPCPS
2260 2270 2280 2290 2300
PCTPEQQESF GGPDACGVIS ATDGPLAPCH GLVPPAQYFQ GCLLDACQVQ
2310 2320 2330 2340 2350
GHPGGLCPAV ATYVAACQAA GAQLREWRRP DFCPFQCPAH SHYELCGDSC
2360 2370 2380 2390 2400
PGSCPSLSAP EGCESACREG CVCDAGFVLS GDTCVPVGQC GCLHDDRYYP
2410 2420 2430 2440 2450
LGQTFYPGPG CDSLCRCREG GEVSCEPSSC GPHETCRPSG GSLGCVAVGS
2460 2470 2480 2490 2500
TTCQASGDPH YTTFDGRRFD FMGTCVYVLA QTCGTRPGLH RFAVLQENVA
2510 2520 2530 2540 2550
WGNGRVSVTR VITVQVANFT LRLEQRQWKV TVNGVDMKLP VVLANGQIRA
2560 2570 2580 2590 2600
SQHGSDVVIE TDFGLRVAYD LVYYVRVTVP GNYYQLMCGL CGNYNGDPKD
2610 2620 2630 2640 2650
DFQKPNGSQA GNANEFGNSW EEVVPDSPCL PPPTCPPGSE GCIPSEECPP
2660 2670 2680 2690 2700
ELEKKYQKEE FCGLLSSPTG PLSSCHKLVD PQGPLKDCIF DLCLGGGNLS
2710 2720 2730 2740 2750
ILCSNIHAYV SACQAAGGQV EPWRNETFCP MECPQNSHYE LCADTCSLGC
2760 2770 2780 2790 2800
SALSAPLQCP DGCAEGCQCD SGFLYNGQAC VPIQQCGCYH NGAYYEPEQT
2810 2820 2830 2840 2850
VLIDNCRQQC TCHVGKVVVC QEHSCKPGQV CQPSGGILSC VNKDPCHGVT
2860 2870 2880 2890 2900
CRPQETCKEQ GGQGVCLPNY EATCWLWGDP HYHSFDGRKF DFQGTCNYVL
2910 2920 2930 2940 2950
ATTGCPGVST QGLTPFTVTT KNQNRGNPAV SYVRVVTVAA LGTNISIHKD
2960 2970 2980 2990 3000
EIGKVRVNGV LTALPVSVAD GRISVTQGAS KALLVADFGL QVSYDWNWRV
3010 3020 3030 3040 3050
DVTLPSSYHG AVCGLCGNMD RNPNNDQVFP NGTLAPSIPI WGGSWRAPGW
3060 3070 3080 3090 3100
DPLCWDECRG SCPTCPEDRL EQYEGPGFCG PLAPGTGGPF TTCHAHVPPE
3110 3120 3130 3140 3150
SFFKGCVLDV CMGGGDRDIL CKALASYVAA CQAAGVVIED WRAQVGCEIT
3160 3170 3180 3190 3200
CPENSHYEVC GPPCPASCPS PAPLTTPAVC EGPCVEGCQC DAGFVLSADR
3210 3220 3230 3240 3250
CVPLNNGCGC WANGTYHEAG SEFWADGTCS QWCRCGPGGG SLVCTPASCG
3260 3270 3280 3290 3300
LGEVCGLLPS GQHGCQPVST AECQAWGDPH YVTLDGHRFD FQGTCEYLLS
3310 3320 3330 3340 3350
APCHGPPLGA ENFTVTVANE HRGSQAVSYT RSVTLQIYNH SLTLSARWPR
3360 3370 3380 3390 3400
KLQVDGVFVT LPFQLDSLLH AHLSGADVVV TTTSGLSLAF DGDSFVRLRV
3410 3420 3430 3440 3450
PAAYAGSLCG LCGNYNQDPA DDLKAVGGKP AGWQVGGAQG CGECVSKPCP
3460 3470 3480 3490 3500
SPCTPEQQES FGGPDACGVI SATDGPLAPC HGLVPPAQYF QGCLLDACQV
3510 3520 3530 3540 3550
QGHPGGLCPA VATYVAACQA AGAQLREWRR PDFCPFQCPA HSHYELCGDS
3560 3570 3580 3590 3600
CPGSCPSLSA PEGCESACRE GCVCDAGFVL SGDTCVPVGQ CGCLHDDRYY
3610 3620 3630 3640 3650
PLGQTFYPGP GCDSLCRCRE GGEVSCEPSS CGPHETCRPS GGSLGCVAVG
3660 3670 3680 3690 3700
STTCQASGDP HYTTFDGHRF DFMGTCVYVL AQTCGTRPGL HRFAVLQENV
3710 3720 3730 3740 3750
AWGNGRVSVT RVITVQVANF TLRLEQRQWK VTVNGVDMKL PVVLANGQIR
3760 3770 3780 3790 3800
ASQHGSDVVI ETDFGLRVAY DLVYYVRVTV PGNYYQLMCG LCGNYNGDPK
3810 3820 3830 3840 3850
DDFQKPNGSQ AGNANEFGNS WEEVVPDSPC LPPPTCPPGS AGCIPSDKCP
3860 3870 3880 3890 3900
PELEKKYQKE EFCGLLSSPT GPLSSCHKLV DPQGPLKDCI FDLCLGGGNL
3910 3920 3930 3940 3950
SILCSNIHAY VSACQAAGGH VEPWRNETFC PMECPQNSHY ELCADTCSLG
3960 3970 3980 3990 4000
CSALSAPLQC PDGCAEGCQC DSGFLYNGQA CVPIQQCGCY HNGVYYEPEQ
4010 4020 4030 4040 4050
TVLIDNCRQQ CTCHVGKVVV CQEHSCKPGQ VCQPSGGILS CVTKDPCHGV
4060 4070 4080 4090 4100
TCRPQETCKE QGGQGVCLPN YEATCWLWGD PHYHSFDGRK FDFQGTCNYV
4110 4120 4130 4140 4150
LATTGCPGVS TQGLTPFTVT TKNQNRGNPA VSYVRVVTVA ALGTNISIHK
4160 4170 4180 4190 4200
DEIGKVRVNG VLTALPVSVA DGRISVAQGA SKALLVADFG LQVSYDWNWR
4210 4220 4230 4240 4250
VDVTLPSSYH GAVCGLCGNM DRNPNNDQVF PNGTLAPSIP IWGGSWRAPG
4260 4270 4280 4290 4300
WDPLCWDECR GSCPTCPEDR LEQYEGPGFC GPLSSGTGGP FTTCHAHVPP
4310 4320 4330 4340 4350
ESFFKGCVLD VCMGGGDRDI LCKALASYVA ACQAAGVVIE DWRAQVGCEI
4360 4370 4380 4390 4400
TCPENSHYEV CGPPCPASCP SPAPLTTPAV CEGPCVEGCQ CDAGFVLSAD
4410 4420 4430 4440 4450
RCVPLNNGCG CWANGTYHEA GSEFWADGTC SQWCRCGPGG GSLVCTPASC
4460 4470 4480 4490 4500
GLGEVCGLLP SGQHGCQPVS TAECQAWGDP HYVTLDGHRF DFQGTCEYLL
4510 4520 4530 4540 4550
SAPCHGPPLG AENFTVTVAN EHRGSQAVSY TRSVTLQIYN HSLTLSARWP
4560 4570 4580 4590 4600
RKLQVDGVFV ALPFQLDSLL HAHLSGADVV VTTTSGLSLA FDGDSFVRLR
4610 4620 4630 4640 4650
VPAAYAASLC GLCGNYNQDP ADDLKAVGGK PAGWQVGGAQ GCGECVSKPC
4660 4670 4680 4690 4700
PSPCTPEQQE SFGGPDACGV ISATDGPLAP CHGLVPPAQY FQGCLLDACQ
4710 4720 4730 4740 4750
VQGHPGGLCP AVATYVAACQ AAGAQLGEWR RPDFCPLQCP AHSHYELCGD
4760 4770 4780 4790 4800
SCPVSCPSLS APEGCESACR EGCVCDAGFV LSGDTCVPVG QCGCLHDGRY
4810 4820 4830 4840 4850
YPLGEVFYPG PECERRCECG PGGHVTCQEG AACGPHEECR LEDGVQACHA
4860 4870 4880 4890 4900
TGCGRCLANG GIHYITLDGR VYDLHGSCSY VLAQVCHPKP GDEDFSIVLE
4910 4920 4930 4940 4950
KNAAGDLQRL LVTVAGQVVS LAQGQQVTVD GEAVALPVAV GRVRVTAEGR
4960 4970 4980 4990 5000
NMVLQTTKGL RLLFDGDAHL LMSIPSPFRG RLCGLCGNFN GNWSDDFVLP
5010 5020 5030 5040 5050
NGSAASSVET FGAAWRAPGS SKGCGEGCGP QGCPVCLAEE TAPYESNEAC
5060 5070 5080 5090 5100
GQLRNPQGPF ATCQAVLSPS EYFRQCVYDL CAQKGDKAFL CRSLAAYTAA
5110 5120 5130 5140 5150
CQAAGVAVKP WRTDSFCPLH CPAHSHYSIC TRTCQGSCAA LSGLTGCTTR
5160 5170 5180 5190 5200
CFEGCECDDR FLLSQGVCIP VQDCGCTHNG RYLPVNSSLL TSDCSERCSC
5210 5220 5230 5240 5250
SSSSGLTCQA AGCPPGRVCE VKAEARNCWA TRGLCVLSVG ANLTTFDGAR
5260 5270 5280 5290 5300
GATTSPGVYE LSSRCPGLQN TIPWYRVVAE VQICHGKTEA VGQVHIFFQD
5310 5320 5330 5340 5350
GMVTLTPNKG VWVNGLRVDL PAEKLASVSV SRTPDGSLLV RQKAGVQVWL
5360 5370 5380 5390 5400
GANGKVAVIV SNDHAGKLCG ACGNFDGDQT NDWHDSQEKP AMEKWRAQDF
5405
SPCYG

Data source: UniProt

Protein Map Collapse protein map

Position of Targeted Peptide Analytes Relative to SNPs, Isoforms, and PTMs

Uniprot Database Entry PhosphoSitePlus ®

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to view detailed assay information below
All other points link out to UniProt


Phosphorylation Acetylation Ubiquitylation Other

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Assay Details for non-CPTAC-1133 Collapse assay details

Data source: Panorama

Official Gene Symbol
FCGBP
Peptide Sequence
GATTSPGVYELSSR
Modification Type
unmodified
Protein - Site of Modification
N/A
Peptide - Site of Modification
N/A
Peptide Start
5251
Peptide End
5264
CPTAC ID
non-CPTAC-1133
Peptide Molecular Mass
1,423.6943
Species
Homo sapiens (Human)
Assay Type
Direct MRM
Matrix
plasma
Submitting Laboratory
UVic-Genome BC Proteomics Centre
Submitting Lab PI
Christoph Borchers

Assay Parameters Collapse assay parameters

Data source: Panorama

Instrument
6490 Triple Quad (Agilent)
Internal Standard
synthetic peptide
Peptide Standard Purity
>95%
Peptide Standard Label Type
13C and 15N at C-terminus R
LC
1290 LC (Agilent)
Column Packing
Zorbax Eclipse Plus C18, 1.8 µm
Column Dimensions
2.1 x 150 mm
Flow Rate
400 µL/min

Chromatograms

Data source: Panorama

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Response Curves

Data source: Panorama

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Retrieving Data

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Repeatability

Data source: Panorama

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  Average intra-assay CV
(within day CV)		 Average inter-assay CV
(between day CV)		 Total CV
equation		 n=
Fragment ion / Transition Low Med High Low Med High Low Med High Low Med High
y9 (2+) 31.8 13 9.5 41.4 14.7 8 52.2 19.6 12.4 13 15 15
y4 (1+) 28.1 11.2 9.4 28.7 11 10.1 40.2 15.7 13.8 12 15 15
y6 (1+) 29.6 11.5 11.1 26.1 11.5 10.6 39.5 16.3 15.3 15 15 15
y9 (1+) 21.8 8.3 5.4 21.3 10.8 8 30.5 13.6 9.7 15 15 15
y10 (1+) 24.9 15 5.9 35.6 17.3 6.8 43.4 22.9 9 11 15 15
sum 8.5 6.8 3.4 10.5 7.9 4.5 13.5 10.4 5.6 15 15 15

Additional Resources and Comments

Resources
Download SOPs
View Peptide in Panorama
View Protein in Panorama
Comments