Official Gene Symbol | Other Aliases |
---|---|
BRCA1 | RNF53 |
Sequence Length (AA) | Molecular Weight (Da) |
---|---|
1863 | 207721 |
Protein Name |
---|
Breast cancer type 1 susceptibility protein |
Sources | |
---|---|
UniProt PhosphoSitePlus ® GeneCards |
Human Protein Atlas |
10 | 20 | 30 | 40 | 50 |
MDLSALRVEE | VQNVINAMQK | ILECPICLEL | IKEPVSTKCD | HIFCKFCMLK |
60 | 70 | 80 | 90 | 100 |
LLNQKKGPSQ | CPLCKNDITK | RSLQESTRFS | QLVEELLKII | CAFQLDTGLE |
110 | 120 | 130 | 140 | 150 |
YANSYNFAKK | ENNSPEHLKD | EVSIIQSMGY | RNRAKRLLQS | EPENPSLQET |
160 | 170 | 180 | 190 | 200 |
SLSVQLSNLG | TVRTLRTKQR | IQPQKTSVYI | ELGSDSSEDT | VNKATYCSVG |
210 | 220 | 230 | 240 | 250 |
DQELLQITPQ | GTRDEISLDS | AKKAACEFSE | TDVTNTEHHQ | PSNNDLNTTE |
260 | 270 | 280 | 290 | 300 |
KRAAERHPEK | YQGSSVSNLH | VEPCGTNTHA | SSLQHENSSL | LLTKDRMNVE |
310 | 320 | 330 | 340 | 350 |
KAEFCNKSKQ | PGLARSQHNR | WAGSKETCND | RRTPSTEKKV | DLNADPLCER |
360 | 370 | 380 | 390 | 400 |
KEWNKQKLPC | SENPRDTEDV | PWITLNSSIQ | KVNEWFSRSD | ELLGSDDSHD |
410 | 420 | 430 | 440 | 450 |
GESESNAKVA | DVLDVLNEVD | EYSGSSEKID | LLASDPHEAL | ICKSERVHSK |
460 | 470 | 480 | 490 | 500 |
SVESNIEDKI | FGKTYRKKAS | LPNLSHVTEN | LIIGAFVTEP | QIIQERPLTN |
510 | 520 | 530 | 540 | 550 |
KLKRKRRPTS | GLHPEDFIKK | ADLAVQKTPE | MINQGTNQTE | QNGQVMNITN |
560 | 570 | 580 | 590 | 600 |
SGHENKTKGD | SIQNEKNPNP | IESLEKESAF | KTKAEPISSS | ISNMELELNI |
610 | 620 | 630 | 640 | 650 |
HNSKAPKKNR | LRRKSSTRHI | HALELVVSRN | LSPPNCTELQ | IDSCSSSEEI |
660 | 670 | 680 | 690 | 700 |
KKKKYNQMPV | RHSRNLQLME | GKEPATGAKK | SNKPNEQTSK | RHDSDTFPEL |
710 | 720 | 730 | 740 | 750 |
KLTNAPGSFT | KCSNTSELKE | FVNPSLPREE | KEEKLETVKV | SNNAEDPKDL |
760 | 770 | 780 | 790 | 800 |
MLSGERVLQT | ERSVESSSIS | LVPGTDYGTQ | ESISLLEVST | LGKAKTEPNK |
810 | 820 | 830 | 840 | 850 |
CVSQCAAFEN | PKGLIHGCSK | DNRNDTEGFK | YPLGHEVNHS | RETSIEMEES |
860 | 870 | 880 | 890 | 900 |
ELDAQYLQNT | FKVSKRQSFA | PFSNPGNAEE | ECATFSAHSG | SLKKQSPKVT |
910 | 920 | 930 | 940 | 950 |
FECEQKEENQ | GKNESNIKPV | QTVNITAGFP | VVGQKDKPVD | NAKCSIKGGS |
960 | 970 | 980 | 990 | 1000 |
RFCLSSQFRG | NETGLITPNK | HGLLQNPYRI | PPLFPIKSFV | KTKCKKNLLE |
1010 | 1020 | 1030 | 1040 | 1050 |
ENFEEHSMSP | EREMGNENIP | STVSTISRNN | IRENVFKEAS | SSNINEVGSS |
1060 | 1070 | 1080 | 1090 | 1100 |
TNEVGSSINE | IGSSDENIQA | ELGRNRGPKL | NAMLRLGVLQ | PEVYKQSLPG |
1110 | 1120 | 1130 | 1140 | 1150 |
SNCKHPEIKK | QEYEEVVQTV | NTDFSPYLIS | DNLEQPMGSS | HASQVCSETP |
1160 | 1170 | 1180 | 1190 | 1200 |
DDLLDDGEIK | EDTSFAENDI | KESSAVFSKS | VQKGELSRSP | SPFTHTHLAQ |
1210 | 1220 | 1230 | 1240 | 1250 |
GYRRGAKKLE | SSEENLSSED | EELPCFQHLL | FGKVNNIPSQ | STRHSTVATE |
1260 | 1270 | 1280 | 1290 | 1300 |
CLSKNTEENL | LSLKNSLNDC | SNQVILAKAS | QEHHLSEETK | CSASLFSSQC |
1310 | 1320 | 1330 | 1340 | 1350 |
SELEDLTANT | NTQDPFLIGS | SKQMRHQSES | QGVGLSDKEL | VSDDEERGTG |
1360 | 1370 | 1380 | 1390 | 1400 |
LEENNQEEQS | MDSNLGEAAS | GCESETSVSE | DCSGLSSQSD | ILTTQQRDTM |
1410 | 1420 | 1430 | 1440 | 1450 |
QHNLIKLQQE | MAELEAVLEQ | HGSQPSNSYP | SIISDSSALE | DLRNPEQSTS |
1460 | 1470 | 1480 | 1490 | 1500 |
EKAVLTSQKS | SEYPISQNPE | GLSADKFEVS | ADSSTSKNKE | PGVERSSPSK |
1510 | 1520 | 1530 | 1540 | 1550 |
CPSLDDRWYM | HSCSGSLQNR | NYPSQEELIK | VVDVEEQQLE | ESGPHDLTET |
1560 | 1570 | 1580 | 1590 | 1600 |
SYLPRQDLEG | TPYLESGISL | FSDDPESDPS | EDRAPESARV | GNIPSSTSAL |
1610 | 1620 | 1630 | 1640 | 1650 |
KVPQLKVAES | AQSPAAAHTT | DTAGYNAMEE | SVSREKPELT | ASTERVNKRM |
1660 | 1670 | 1680 | 1690 | 1700 |
SMVVSGLTPE | EFMLVYKFAR | KHHITLTNLI | TEETTHVVMK | TDAEFVCERT |
1710 | 1720 | 1730 | 1740 | 1750 |
LKYFLGIAGG | KWVVSYFWVT | QSIKERKMLN | EHDFEVRGDV | VNGRNHQGPK |
1760 | 1770 | 1780 | 1790 | 1800 |
RARESQDRKI | FRGLEICCYG | PFTNMPTDQL | EWMVQLCGAS | VVKELSSFTL |
1810 | 1820 | 1830 | 1840 | 1850 |
GTGVHPIVVV | QPDAWTEDNG | FHAIGQMCEA | PVVTREWVLD | SVALYQCQEL |
1860 | 1863 | |||
DTYLIPQIPH | SHY |
Data source: UniProt
Uniprot Database Entry PhosphoSitePlus ®
loading
Data source: Panorama
View Details (opens in a new window)
Kennedy JJ, Yan P, Zhao L, Ivey RG, Voytovich U, Moore HD, Lin C, Pogosova-Agadjanyan EL, Stirewalt DL, Reding KW, Whiteaker JR, Paulovich AG. Immobilized metal affinity chromatography coupled to multiple reaction monitoring enables reproducible quantification of phospho-signaling. Molecular and Cellular Proteomics. mcp.O115.054940
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y8 (2+) | 21.8 | 7.9 | 8 | 18.7 | 8.4 | 8.9 | 28.7 | 11.5 | 12 | 15 | 24 | 15 |
y8-98 (1+) | 20.3 | 6.1 | 8.4 | 14.7 | 8.6 | 9.6 | 25.1 | 10.5 | 12.8 | 15 | 24 | 15 |
y8 (1+) | 25 | 10.3 | 11.1 | 20.8 | 11.4 | 11.3 | 32.5 | 15.4 | 15.8 | 15 | 24 | 15 |
sum | 20.2 | 6.3 | 6.7 | 16.2 | 7.7 | 6.6 | 25.9 | 9.9 | 9.4 | 15 | 24 | 15 |
Data source: Panorama
View Details (opens in a new window)
A Multiplexed Mass Spectrometry-Based Assay for Robust Quantification of Phosphosignaling in Response to DNA Damage. Whiteaker JR, Zhao L, Saul R, Kaczmarczyk JA, Schoenherr RM, Moore HD, Jones-Weinert C, Ivey RG, Lin C, Hiltke T, Reding KW, Whiteley G, Wang P, Paulovich AG. Radiat Res. 2018 Feb 23. doi: 10.1667/RR14963.1. [Epub ahead of print]
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y8 (1+) | 12.1 | 5.1 | 6.8 | 15.5 | 5.3 | 10.4 | 19.7 | 7.4 | 12.4 | 15 | 15 | 15 |
y7 (1+) | 17.3 | 8.8 | 11.8 | 24.2 | 16.6 | 8.9 | 29.7 | 18.8 | 14.8 | 15 | 15 | 15 |
y8 (2+) | 11.2 | 10.1 | 9 | 10.4 | 13.4 | 11.8 | 15.3 | 16.8 | 14.8 | 15 | 15 | 15 |
sum | 9.8 | 4.1 | 5.3 | 10.3 | 7.7 | 6.6 | 14.2 | 8.7 | 8.5 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
A Multiplexed Mass Spectrometry-Based Assay for Robust Quantification of Phosphosignaling in Response to DNA Damage. Whiteaker JR, Zhao L, Saul R, Kaczmarczyk JA, Schoenherr RM, Moore HD, Jones-Weinert C, Ivey RG, Lin C, Hiltke T, Reding KW, Whiteley G, Wang P, Paulovich AG. Radiat Res. 2018 Feb 23. doi: 10.1667/RR14963.1. [Epub ahead of print]
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y8 (1+) | 17.1 | 6.1 | 6.9 | 41.2 | 9 | 7.7 | 44.6 | 10.9 | 10.3 | 15 | 15 | 15 |
y8-98 (1+) | 16.8 | 6.4 | 5.5 | 31 | 7.1 | 5.4 | 35.3 | 9.6 | 7.7 | 15 | 15 | 15 |
y7 (1+) | 28.8 | 10.2 | 13.8 | 52.7 | 13.5 | 17.9 | 60.1 | 16.9 | 22.6 | 15 | 15 | 15 |
y8 (2+) | 13.4 | 4 | 4.4 | 37.3 | 7.5 | 4.7 | 39.6 | 8.5 | 6.4 | 15 | 15 | 15 |
sum | 7.8 | 3.5 | 3.7 | 35.7 | 6.7 | 4.7 | 36.5 | 7.6 | 6 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y7 (1+) | 7 | 3.6 | 3.8 | 5.3 | 7.3 | 4.7 | 8.8 | 8.1 | 6 | 15 | 15 | 15 |
y6 (1+) | 26.2 | 4.6 | 4.6 | 18.9 | 8.8 | 6.6 | 32.3 | 9.9 | 8 | 15 | 15 | 15 |
y5 (1+) | 66.9 | 16.5 | 11.4 | 65.7 | 16.7 | 11.1 | 93.8 | 23.5 | 15.9 | 15 | 15 | 15 |
sum | 8.6 | 3.5 | 3.6 | 5 | 7.3 | 4.3 | 9.9 | 8.1 | 5.6 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
y11 (1+) | 17.1 | 15.6 | 12.2 | 15.7 | 20.1 | 15.5 | 23.2 | 25.4 | 19.7 | 15 | 15 | 15 |
y10 (1+) | 35.2 | 21 | 16.3 | 33.2 | 25.6 | 17.6 | 48.4 | 33.1 | 24 | 15 | 15 | 15 |
y9 (1+) | 38.8 | 21.6 | 20.4 | 50.4 | 30.2 | 18.1 | 63.6 | 37.1 | 27.3 | 15 | 15 | 15 |
sum | 11.6 | 14.8 | 11 | 12.3 | 21 | 13 | 16.9 | 25.7 | 17 | 15 | 15 | 15 |
Comments