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Please include the following statement when referencing the CPTAC Assay Portal
We would like to acknowledge the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) Assay Portal (assays.cancer.gov) for developing assays and establishing criteria for the assays described in this publication.

Overview Data source: UniProt

Official Gene Symbol Other Aliases
Qsox1 Qscn6, Sox
Sequence Length (AA) Molecular Weight (Da)
748 82785
Protein Name
Sulfhydryl oxidase 1
Sources
UniProt
PhosphoSitePlus ®
GeneCards
Human Protein Atlas

Protein Sequence hover to view complete sequence

10 20 30 40 50
MRRCGRLSGP PSLLLLLLLL SPLLFSGPGA YAARLSVLYS SSDPLTLLDA
60 70 80 90 100
DSVRPTVLGS SSAWAVEFFA SWCGHCIAFA PTWKELANDV KDWRPALNLA
110 120 130 140 150
VLDCAEETNS AVCREFNIAG FPTVRFFQAF TKNGSGATLP GAGANVQTLR
160 170 180 190 200
MRLIDALESH RDTWPPACPP LEPAKLNDID GFFTRNKADY LALVFEREDS
210 220 230 240 250
YLGREVTLDL SQYHAVAVRR VLNTESDLVN KFGVTDFPSC YLLLRNGSVS
260 270 280 290 300
RVPVLVESRS FYTSYLRGLP GLTRDAPPTT ATPVTADKIA PTVWKFADRS
310 320 330 340 350
KIYMADLESA LHYILRVEVG KFSVLEGQRL VALKKFVAVL AKYFPGQPLV
360 370 380 390 400
QNFLHSINDW LQKQQKKRIP YSFFKAALDS RKEDAVLTEK VNWVGCQGSE
410 420 430 440 450
PHFRGFPCSL WVLFHFLTVQ ANRYSEAHPQ EPADGQEVLQ AMRSYVQFFF
460 470 480 490 500
GCRDCADHFE QMAAASMHQV RSPSNAILWL WTSHNRVNAR LSGALSEDPH
510 520 530 540 550
FPKVQWPPRE LCSACHNELN GQVPLWDLGA TLNFLKAHFS PANIVIDSSA
560 570 580 590 600
SRHTGRRGSP EATPELVMDT LKLESRNSVL GHEQAASAES PGATALDVPA
610 620 630 640 650
EKPEASGPQE LYTGLRMGGA SPGQGPPERM EDHQRDMQEN APGQQHLSKR
660 670 680 690 700
DTEALFLPEV NHLQGPLELR RGGRSPKQLA PILEEEPEAL AIQGQGQWLQ
710 720 730 740 748
VLGGGISHLD ISLCVGLYSV SFMGLLAMYT YFRARLRTPK GHASYPTA

Data source: UniProt


Position of Targeted Peptide Analytes Relative to SNPs, Isoforms, and PTMs

Uniprot Database Entry PhosphoSitePlus ®

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to view detailed assay information below
All other points link out to UniProt



Phosphorylation Acetylation Ubiquitylation Other

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Assay Details for non-CPTAC-3297 Collapse assay details

Data source: Panorama

Official Gene Symbol
Qsox1
Peptide Sequence
EFNIAGFPTVR
Modification Type
unmodified
Protein - Site of Modification
N/A
Peptide - Site of Modification
N/A
Peptide Start
115
Peptide End
125
CPTAC ID
non-CPTAC-3297
Peptide Molecular Mass
1,249.6455
Species
Mus musculus (Mouse)
Assay Type
Direct MRM
Matrix
Plasma
Submitting Laboratory
UVic-Genome BC Proteomics Centre
Submitting Lab PI
Christoph Borchers

Publication

View Details (opens in a new window)

Molecular phenotyping of laboratory mouse strains using 500 multiple reaction monitoring mass spectrometry plasma assays. Michaud SA, Sinclair NJ, Petrošová H, Palmer AL, Pistawka AJ, Zhang S, Hardie DB, Mohammed Y Eshghi A1, Richard VR, Sickmann A, Borchers CH. Commun Biol. 2018 Jun 27;1:78. doi: 10.1038/s42003-018-0087-6. eCollection 2018.


Assay Parameters Collapse assay parameters

Data source: Panorama

Instrument
Agilent 6490/6495 QQQ
Internal Standard
synthetic peptide
Peptide Standard Purity
>95%
Peptide Standard Label Type
13C and 15N at C-terminus R
LC
1290 LC (Agilent)
Column Packing
Zorbax Eclipse Plus C18, 1.8 µm
Column Dimensions
2.1 x 150 mm
Flow Rate
400 µL/min

Chromatograms

Data source: Panorama


Response Curves

Data source: Panorama

Retrieving Data

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Repeatability

Data source: Panorama

  Average intra-assay CV
(within day CV)
Average inter-assay CV
(between day CV)
Total CV
equation
n=
Fragment ion / Transition Low Med High Low Med High Low Med High Low Med High
y9 (1+) 6.8 3.2 4.4 11.4 5.4 5 13.3 6.3 6.7 15 15 15
y7 (1+) 5.9 3 2.9 14.5 6.6 5.3 15.7 7.2 6 15 15 15
y6 (1+) 4 3 3.3 12.9 6.4 4 13.5 7.1 5.2 15 15 15
b4 (1+) 8.5 4.2 4.4 12 8 5.9 14.7 9 7.4 15 15 15
y4 (1+) 4.5 4.4 3.2 14.5 7.2 4.3 15.2 8.4 5.4 15 15 15
sum 2.7 1.6 1.7 12.7 5.9 3.1 13 6.1 3.5 15 15 15


Additional Resources and Comments