| Official Gene Symbol | Other Aliases |
|---|---|
| ATF4 | CREB2, TXREB |
| Sequence Length (AA) | Molecular Weight (Da) |
|---|---|
| 351 | 38590 |
| Protein Name |
|---|
| Cyclic AMP-dependent transcription factor ATF-4 |
| Sources | |
|---|---|
|
UniProt PhosphoSitePlus ® GeneCards |
Human Protein Atlas |
| 10 | 20 | 30 | 40 | 50 |
| MTEMSFLSSE | VLVGDLMSPF | DQSGLGAEES | LGLLDDYLEV | AKHFKPHGFS |
| 60 | 70 | 80 | 90 | 100 |
| SDKAKAGSSE | WLAVDGLVSP | SNNSKEDAFS | GTDWMLEKMD | LKEFDLDALL |
| 110 | 120 | 130 | 140 | 150 |
| GIDDLETMPD | DLLTTLDDTC | DLFAPLVQET | NKQPPQTVNP | IGHLPESLTK |
| 160 | 170 | 180 | 190 | 200 |
| PDQVAPFTFL | QPLPLSPGVL | SSTPDHSFSL | ELGSEVDITE | GDRKPDYTAY |
| 210 | 220 | 230 | 240 | 250 |
| VAMIPQCIKE | EDTPSDNDSG | ICMSPESYLG | SPQHSPSTRG | SPNRSLPSPG |
| 260 | 270 | 280 | 290 | 300 |
| VLCGSARPKP | YDPPGEKMVA | AKVKGEKLDK | KLKKMEQNKT | AATRYRQKKR |
| 310 | 320 | 330 | 340 | 350 |
| AEQEALTGEC | KELEKKNEAL | KERADSLAKE | IQYLKDLIEE | VRKARGKKRV |
| 351 | ||||
| P |
Data source: UniProt
Uniprot Database Entry PhosphoSitePlus ®
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Data source: Panorama
View Details (opens in a new window)
mTORC1-driven protein translation correlates with clinical benefit of capivasertib within a genetically preselected cohort of PIK3CA-altered tumours. Constance A Sobsey, Bjoern C Froehlich, Georgia Mitsa, Sahar Ibrahim, Robert Popp, Rene P Zahedi, Elza C de Bruin, Christoph H Borchers, Gerald Batist
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| b12 (1+) | 18.3 | 4.4 | 5.4 | 23.1 | 4.7 | 6 | 29.5 | 6.4 | 8.1 | 15 | 16 | 17 |
| y6 (1+) | 16.1 | 4.5 | 3.2 | 20.9 | 4.8 | 3 | 26.4 | 6.6 | 4.4 | 15 | 16 | 17 |
| y7 (1+) | 19.2 | 4.5 | 4.6 | 22.7 | 4.8 | 4.5 | 29.7 | 6.6 | 6.4 | 15 | 16 | 17 |
| y6 (2+) | 16.9 | 5.6 | 5.3 | 23.3 | 5.3 | 4.9 | 28.8 | 7.7 | 7.2 | 15 | 16 | 17 |
| y7 (2+) | 16.7 | 6.6 | 4.9 | 20 | 7.2 | 5.2 | 26.1 | 9.8 | 7.1 | 15 | 16 | 17 |
| sum | 13.5 | 2.2 | 1.2 | 19.2 | 2.4 | 1.3 | 23.5 | 3.3 | 1.8 | 15 | 16 | 17 |
Data source: Panorama
| Fragment ion / Transition | control_intra_CV | actual_temp_intra_CV | frozen_intra_CV | FTx1_intra_CV | FTx2_intra_CV |
|---|---|---|---|---|---|
| b12 (1+) | 11.5 | 4.5 | 6.8 | 4.4 | 2.2 |
| y6 (1+) | 4.2 | 4.9 | 3.7 | 10.4 | 2.5 |
| y7 (1+) | 7.5 | 4.7 | 6.3 | 4 | 12.9 |
| y6 (2+) | 5.7 | 4.7 | 5.2 | 5 | 1.3 |
| y7 (2+) | 10.6 | 5.9 | 4.4 | 3.9 | 3.9 |
| sum | 3.4 | 1.2 | 2.1 | 3.3 | 3.7 |
| Fragment ion / Transition | all_intra_CV | all_inter_CV |
|---|---|---|
| b12 (1+) | 5.6 | 7.5 |
| y6 (1+) | 5.1 | 7.7 |
| y7 (1+) | 6.7 | 7.5 |
| y6 (2+) | 4.5 | 4 |
| y7 (2+) | 5.8 | 7.2 |
| sum | 2.5 | 3.7 |
Data source: Panorama
| Fragment ion / Transition | intra_CV | inter_CV | total_CV |
|---|---|---|---|
| b12 (1+) | 90.8 | 132.1 | 160.3 |
| y6 (1+) | 70.9 | 63.1 | 94.9 |
| y7 (1+) | 2 | 49.1 | 49.1 |
| y6 (2+) | 9 | 27.7 | 29.1 |
| y7 (2+) | 78.2 | 76 | 109 |
| sum | 43.8 | 44.2 | 62.2 |
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