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Overview Data source: UniProt

Official Gene Symbol Other Aliases
C1qc C1qg
Sequence Length (AA) Molecular Weight (Da)
246 25992
Protein Name
Complement C1q subcomponent subunit C
Sources
UniProt
PhosphoSitePlus ®
GeneCards
Human Protein Atlas

Protein Sequence hover to view complete sequence

10 20 30 40 50
MVVGPSCQPP CGLCLLLLFL LALPLRSQAS AGCYGIPGMP GMPGAPGKDG
60 70 80 90 100
HDGLQGPKGE PGIPAVPGTR GPKGQKGEPG MPGHRGKNGP RGTSGLPGDP
110 120 130 140 150
GPRGPPGEPG VEGRYKQKHQ SVFTVTRQTT QYPEANALVR FNSVVTNPQG
160 170 180 190 200
HYNPSTGKFT CEVPGLYYFV YYTSHTANLC VHLNLNLARV ASFCDHMFNS
210 220 230 240 246
KQVSSGGVLL RLQRGDEVWL SVNDYNGMVG IEGSNSVFSG FLLFPD

Data source: UniProt


Position of Targeted Peptide Analytes Relative to SNPs, Isoforms, and PTMs

Uniprot Database Entry PhosphoSitePlus ®

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All other points link out to UniProt



Phosphorylation Acetylation Ubiquitylation Other

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Assay Details for non-CPTAC-2652 Collapse assay details

Data source: Panorama

Official Gene Symbol
C1QC
Peptide Sequence
FNAVLTNPQGDYDTSTGK
Modification Type
unmodified
Protein - Site of Modification
N/A
Peptide - Site of Modification
N/A
Peptide Start
140
Peptide End
157
CPTAC ID
non-CPTAC-2652
Peptide Molecular Mass
1,926.8959
Species
Homo sapiens (Human)
Assay Type
Direct MRM
Matrix
plasma
Submitting Laboratory
UVic-Genome BC Proteomics Centre
Submitting Lab PI
Christoph Borchers

Assay Parameters Collapse assay parameters

Data source: Panorama

Instrument
6490 Triple Quad (Agilent)
Internal Standard
synthetic peptide
Peptide Standard Purity
>95%
Peptide Standard Label Type
13C and 15N at C-terminus K
LC
1290 LC (Agilent)
Column Packing
Zorbax Eclipse Plus C18, 1.8 µm
Column Dimensions
2.1 x 150 mm
Flow Rate
400 µL/min

Chromatograms

Data source: Panorama


Response Curves

Data source: Panorama

Retrieving Data

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Repeatability

Data source: Panorama

  Average intra-assay CV
(within day CV)
Average inter-assay CV
(between day CV)
Total CV
equation
n=
Fragment ion / Transition Low Med High Low Med High Low Med High Low Med High
y11 (2+) 11.3 7.9 6.4 12.1 9.2 9.4 16.6 12.1 11.4 15 15 15
b2 (1+) 11.5 5.1 5.7 11.5 11.1 7.7 16.3 12.2 9.6 15 15 15
y9 (1+) 9.5 4.4 4.7 18.1 4.9 11.9 20.4 6.6 12.8 15 15 15
y14 (2+) 10.4 7 3.4 13.9 8.9 4.4 17.4 11.3 5.6 15 15 15
b3 (1+) 7.2 7.8 6.9 13.6 9.1 6.6 15.4 12 9.5 15 15 15
sum 6.4 4.8 3.4 9.5 6.9 4.9 11.5 8.4 6 15 15 15

Additional Resources and Comments


Assay Details for non-CPTAC-3357 Collapse assay details

Data source: Panorama

Official Gene Symbol
C1qc
Peptide Sequence
FNSVVTNPQGHYNPSTGK
Modification Type
unmodified
Protein - Site of Modification
N/A
Peptide - Site of Modification
N/A
Peptide Start
141
Peptide End
158
CPTAC ID
non-CPTAC-3357
Peptide Molecular Mass
1,945.9282
Species
Mus musculus (Mouse)
Assay Type
Direct MRM
Matrix
Plasma
Submitting Laboratory
UVic-Genome BC Proteomics Centre
Submitting Lab PI
Christoph Borchers

Publication

View Details (opens in a new window)

Molecular phenotyping of laboratory mouse strains using 500 multiple reaction monitoring mass spectrometry plasma assays. Michaud SA, Sinclair NJ, Petrošová H, Palmer AL, Pistawka AJ, Zhang S, Hardie DB, Mohammed Y Eshghi A1, Richard VR, Sickmann A, Borchers CH. Commun Biol. 2018 Jun 27;1:78. doi: 10.1038/s42003-018-0087-6. eCollection 2018.


Assay Parameters Collapse assay parameters

Data source: Panorama

Instrument
Agilent 6490/6495 QQQ
Internal Standard
synthetic peptide
Peptide Standard Purity
>95%
Peptide Standard Label Type
13C and 15N at C-terminus K
LC
1290 LC (Agilent)
Column Packing
Zorbax Eclipse Plus C18, 1.8 µm
Column Dimensions
2.1 x 150 mm
Flow Rate
400 µL/min

Chromatograms

Data source: Panorama


Response Curves

Data source: Panorama

Retrieving Data

Loader

Repeatability

Data source: Panorama

  Average intra-assay CV
(within day CV)
Average inter-assay CV
(between day CV)
Total CV
equation
n=
Fragment ion / Transition Low Med High Low Med High Low Med High Low Med High
b2 (1+) 6.2 5.5 5.1 18 10 6.6 19 11.4 8.3 15 15 15
y13 (2+) 8.6 5.1 10.2 14.9 9.7 6.7 17.2 11 12.2 15 15 15
y14 (2+) 7.7 5.4 10 16.7 9.6 8.4 18.4 11 13.1 15 15 15
y15 (2+) 8.5 7.9 7.8 11.7 7.8 9.1 14.5 11.1 12 15 15 15
y16 (2+) 9.8 3.9 12.1 15.9 7.9 14.1 18.7 8.8 18.6 15 15 15
sum 4.3 2.8 4.9 14.4 7.1 5.8 15 7.6 7.6 15 15 15

Additional Resources and Comments


Assay Details for non-CPTAC-3302 Collapse assay details

Data source: Panorama

Official Gene Symbol
C1qc
Peptide Sequence
QTTQYPEANALVR
Modification Type
unmodified
Protein - Site of Modification
N/A
Peptide - Site of Modification
N/A
Peptide Start
128
Peptide End
140
CPTAC ID
non-CPTAC-3302
Peptide Molecular Mass
1,489.7525
Species
Mus musculus (Mouse)
Assay Type
Direct MRM
Matrix
Plasma
Submitting Laboratory
UVic-Genome BC Proteomics Centre
Submitting Lab PI
Christoph Borchers

Assay Parameters Collapse assay parameters

Data source: Panorama

Instrument
Agilent 6490/6495 QQQ
Internal Standard
synthetic peptide
Peptide Standard Purity
>95%
Peptide Standard Label Type
13C and 15N at C-terminus R
LC
1290 LC (Agilent)
Column Packing
Zorbax Eclipse Plus C18, 1.8 µm
Column Dimensions
2.1 x 150 mm
Flow Rate
400 µL/min

Chromatograms

Data source: Panorama


Response Curves

Data source: Panorama

Retrieving Data

Loader

Repeatability

Data source: Panorama

  Average intra-assay CV
(within day CV)
Average inter-assay CV
(between day CV)
Total CV
equation
n=
Fragment ion / Transition Low Med High Low Med High Low Med High Low Med High
b2 (1+) 18.6 4.7 7.5 33.5 6.1 12.2 38.3 7.7 14.3 15 15 15
b3 (1+) 26.1 9 7.8 36.4 8.5 11.7 44.8 12.4 14.1 15 15 15
b5 (1+) 18.2 7.1 7 20.5 6.7 8.8 27.4 9.8 11.2 15 15 15
y9 (1+) 10.8 4.7 8 17.5 8.1 10 20.6 9.4 12.8 15 15 15
y8 (1+) 11.1 6.8 8.6 13.9 5.9 9.5 17.8 9 12.8 15 15 15
sum 8.8 4.3 5.2 12.9 4.9 7.4 15.6 6.5 9 15 15 15

Additional Resources and Comments