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Please include the following statement when referencing the CPTAC Assay Portal
We would like to acknowledge the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) Assay Portal (assays.cancer.gov) for developing assays and establishing criteria for the assays described in this publication.

Overview Data source: UniProt

Official Gene Symbol Other Aliases
Corin Crn, Lrp4
Sequence Length (AA) Molecular Weight (Da)
1113 123006
Protein Name
Atrial natriuretic peptide-converting enzyme
Sources
UniProt
PhosphoSitePlus ®
GeneCards
Human Protein Atlas

Protein Sequence hover to view complete sequence

10 20 30 40 50
MGRVSFSVRV SSVRRARCSC PGRCYLSCRV PPTTALRALN GLGCAGVPGE
60 70 80 90 100
TAGGAVGPGP LGTRGFLSGS KFQAPGSWKD CFGAPPAPDV LRADRSVGEG
110 120 130 140 150
CPQKLVTANL LRFLLLVLIP CICALIVLLA ILLSFVGTLK RVYFKSNDSE
160 170 180 190 200
PLVTDGEARV PGVIPVNTVY YENTGAPSLP PSQSTPAWTP RAPSPEDQSH
210 220 230 240 250
RNTSTCMNIT HSQCQILPYH STLAPLLPIV KNMDMEKFLK FFTYLHRLSC
260 270 280 290 300
YQHILLFGCS LAFPECVVDG DDRHGLLPCR SFCEAAKEGC ESVLGMVNSS
310 320 330 340 350
WPDSLRCSQF RDHTETNSSV RKSCFSLQQE HGKQSLCGGG ESFLCTSGLC
360 370 380 390 400
VPKKLQCNGY NDCDDWSDEA HCNCSKDLFH CGTGKCLHYS LLCDGYDDCG
410 420 430 440 450
DLSDEQNCDC NLTKEHRCGD GRCIAAEWVC DGDHDCVDKS DEVNCSCHSQ
460 470 480 490 500
GLVECRSGQC IPSTFQCDGD EDCKDGSDEE NCSDSQTPCP EGEQGCLGSS
510 520 530 540 550
CVESCAGSSL CDSDSSLSNC SQCEPITLEL CMNLPYNHTH YPNYLGHRTQ
560 570 580 590 600
KEASISWESS LFPALVQTNC YKYLMFFACT ILVPKCDVNT GQRIPPCRLL
610 620 630 640 650
CEHSKERCES VLGIVGLQWP EDTDCNQFPE ESSDNQTCLL PNEDVEECSP
660 670 680 690 700
SHFKCRSGRC VLGSRRCDGQ ADCDDDSDEE NCGCKERALW ECPFNKQCLK
710 720 730 740 750
HTLICDGFPD CPDSMDEKNC SFCQDNELEC ANHECVPRDL WCDGWVDCSD
760 770 780 790 800
SSDEWGCVTL SKNGNSSSLL TVHKSAKEHH VCADGWRETL SQLACKQMGL
810 820 830 840 850
GEPSVTKLIP GQEGQQWLRL YPNWENLNGS TLQELLVYRH SCPSRSEISL
860 870 880 890 900
LCSKQDCGRR PAARMNKRIL GGRTSRPGRW PWQCSLQSEP SGHICGCVLI
910 920 930 940 950
AKKWVLTVAH CFEGREDADV WKVVFGINNL DHPSGFMQTR FVKTILLHPR
960 970 980 990 1000
YSRAVVDYDI SVVELSDDIN ETSYVRPVCL PSPEEYLEPD TYCYITGWGH
1010 1020 1030 1040 1050
MGNKMPFKLQ EGEVRIIPLE QCQSYFDMKT ITNRMICAGY ESGTVDSCMG
1060 1070 1080 1090 1100
DSGGPLVCER PGGQWTLFGL TSWGSVCFSK VLGPGVYSNV SYFVGWIERQ
1110 1113
IYIQTFLQKK SQG

Data source: UniProt


Position of Targeted Peptide Analytes Relative to SNPs, Isoforms, and PTMs

Uniprot Database Entry PhosphoSitePlus ®

Click a point on a node
to view detailed assay information below
All other points link out to UniProt



Phosphorylation Acetylation Ubiquitylation Other

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Assay Details for non-CPTAC-3454 Collapse assay details

Data source: Panorama

Official Gene Symbol
Corin
Peptide Sequence
TILLHPR
Modification Type
unmodified
Protein - Site of Modification
N/A
Peptide - Site of Modification
N/A
Peptide Start
944
Peptide End
950
CPTAC ID
non-CPTAC-3454
Peptide Molecular Mass
848.5232
Species
Mus musculus (Mouse)
Assay Type
Direct MRM
Matrix
Plasma
Submitting Laboratory
UVic-Genome BC Proteomics Centre
Submitting Lab PI
Christoph Borchers

Assay Parameters Collapse assay parameters

Data source: Panorama

Instrument
Agilent 6490/6495 QQQ
Internal Standard
synthetic peptide
Peptide Standard Purity
>95%
Peptide Standard Label Type
13C and 15N at C-terminus R
LC
1290 LC (Agilent)
Column Packing
Zorbax Eclipse Plus C18, 1.8 µm
Column Dimensions
2.1 x 150 mm
Flow Rate
400 µL/min

Chromatograms

Data source: Panorama


Response Curves

Data source: Panorama

Retrieving Data

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Repeatability

Data source: Panorama

  Average intra-assay CV
(within day CV)
Average inter-assay CV
(between day CV)
Total CV
equation
n=
Fragment ion / Transition Low Med High Low Med High Low Med High Low Med High
b2 (1+) 8 4.2 5.3 11.8 6.7 6.1 14.3 7.9 8.1 15 15 15
y5 (2+) 10.9 8 6.7 13.1 6.2 9.2 17 10.1 11.4 15 15 15
y2 (1+) 11.5 5 3.8 15.9 8.7 4.9 19.6 10 6.2 15 15 15
y4 (1+) 7.9 3.9 7.3 12 6.8 6.7 14.4 7.8 9.9 15 15 15
y5 (1+) 8.2 6.6 6.8 11.7 10 9 14.3 12 11.3 15 15 15
sum 5.3 2.6 3.5 8.5 4.9 3.8 10 5.5 5.2 15 15 15


Additional Resources and Comments