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Overview Data source: UniProt

Official Gene Symbol Other Aliases
Ica N/A
Sequence Length (AA) Molecular Weight (Da)
700 76766
Protein Name
Inhibitor of carbonic anhydrase
Sources
UniProt
PhosphoSitePlus ®
GeneCards
Human Protein Atlas

Protein Sequence hover to view complete sequence

10 20 30 40 50
MRLLICALLC LGTLGLCLAL PEKTIRWCVV SDHEATKCSS FRDNMKKVLP
60 70 80 90 100
AGGPAVTCVR KMSHPECIRD ISANKVDAVT VDGALVAEAD LPHHSLKPIM
110 120 130 140 150
AEYYGSKDDP KTHYYVVAMA KKGTGFQLNQ LRGKKSCHTG LGWSAGWYVP
160 170 180 190 200
LSTLLPSGSR ETAAATFFSS SCVPCADGKM FPSLCQLCAG KGTDKCACSS
210 220 230 240 250
REPYFGSWGA LKCLQDGTAD VSFVKHLTVF EAMPTKADRD QYELLCMDNT
260 270 280 290 300
RRPVEEYEQC YLARVPSHVV VARSVDGKED SIQELLRVAQ EHFGKDKSSP
310 320 330 340 350
FQLFGSPHGE DLLFTDAAHG LLRVPRKIDI SLYLGYEFLS AFRNLKRGLE
360 370 380 390 400
DSQRVKWCAV GQQERTKCDQ WSAVSGGALA CATEETPEDC IAATMKGEAD
410 420 430 440 450
AMSLDGGFAY VAGHCGLVPV LAENYLSTHS SGRLGSKCVN APLEGYYVVA
460 470 480 490 500
VVKKSDVGIT WKSLQGKKSC HTAVGTSEGW NVPMGLIYNQ TGSCKFDAFF
510 520 530 540 550
SRSCAPGSDP DSPLCALCVG GNNPAHMCAA NNAEGYHGSS GALRCLVEKG
560 570 580 590 600
DVAFMKHPTV LQNTDGKNPE PWAKGLKHED FELLCLDGTR KPVTEAQSCH
610 620 630 640 650
LARVPNRAVF SRKDKADFVR RILFNQQELF GRNGFEYMMF QMFESSAKDL
660 670 680 690 700
LFSDDTECLS NLQNKTTYKT YLGPQYLTLM DNFRQCLSSE LLDACTFHKY

Data source: UniProt


Position of Targeted Peptide Analytes Relative to SNPs, Isoforms, and PTMs

Uniprot Database Entry PhosphoSitePlus ®

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Phosphorylation Acetylation Ubiquitylation Other

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Assay Details for non-CPTAC-3549 Collapse assay details

Data source: Panorama

Official Gene Symbol
Ica
Peptide Sequence
ILFNQQELFGR
Modification Type
unmodified
Protein - Site of Modification
N/A
Peptide - Site of Modification
N/A
Peptide Start
622
Peptide End
632
CPTAC ID
non-CPTAC-3549
Peptide Molecular Mass
1,363.7248
Species
Mus musculus (Mouse)
Assay Type
Direct MRM
Matrix
Plasma
Submitting Laboratory
UVic-Genome BC Proteomics Centre
Submitting Lab PI
Christoph Borchers

Publication

View Details (opens in a new window)

Molecular phenotyping of laboratory mouse strains using 500 multiple reaction monitoring mass spectrometry plasma assays. Michaud SA, Sinclair NJ, Petrošová H, Palmer AL, Pistawka AJ, Zhang S, Hardie DB, Mohammed Y Eshghi A1, Richard VR, Sickmann A, Borchers CH. Commun Biol. 2018 Jun 27;1:78. doi: 10.1038/s42003-018-0087-6. eCollection 2018.


Assay Parameters Collapse assay parameters

Data source: Panorama

Instrument
Agilent 6490/6495 QQQ
Internal Standard
synthetic peptide
Peptide Standard Purity
>95%
Peptide Standard Label Type
13C and 15N at C-terminus R
LC
1290 LC (Agilent)
Column Packing
Zorbax Eclipse Plus C18, 1.8 µm
Column Dimensions
2.1 x 150 mm
Flow Rate
400 µL/min

Chromatograms

Data source: Panorama


Response Curves

Data source: Panorama

Retrieving Data

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Repeatability

Data source: Panorama

  Average intra-assay CV
(within day CV)
Average inter-assay CV
(between day CV)
Total CV
equation
n=
Fragment ion / Transition Low Med High Low Med High Low Med High Low Med High
y9 (2+) 3.5 7.2 3.5 15.5 4.9 5.2 15.9 8.7 6.3 15 15 15
y2 (1+) 8.6 4.2 2.8 11.6 5.3 6.3 14.4 6.8 6.9 15 15 15
y8 (1+) 6.7 4.4 3.8 16 4.1 6.5 17.3 6 7.5 15 15 15
y9 (1+) 8.4 4.1 4.5 19.8 16.8 9.2 21.5 17.3 10.2 15 15 15
b2 (1+) 4.4 3.2 4.5 15.8 4.9 7 16.4 5.9 8.3 15 15 15
sum 2.9 3.1 0.9 15.1 5.4 3.9 15.4 6.2 4 15 15 15


Additional Resources and Comments