| Official Gene Symbol | Other Aliases |
|---|---|
| HSPB1 | HSP27, HSP28 |
| Sequence Length (AA) | Molecular Weight (Da) |
|---|---|
| 205 | 22783 |
| Protein Name |
|---|
| Heat shock protein beta-1 |
| Sources | |
|---|---|
|
UniProt PhosphoSitePlus ® GeneCards |
Human Protein Atlas |
| 10 | 20 | 30 | 40 | 50 |
| MTERRVPFSL | LRGPSWDPFR | DWYPHSRLFD | QAFGLPRLPE | EWSQWLGGSS |
| 60 | 70 | 80 | 90 | 100 |
| WPGYVRPLPP | AAIESPAVAA | PAYSRALSRQ | LSSGVSEIRH | TADRWRVSLD |
| 110 | 120 | 130 | 140 | 150 |
| VNHFAPDELT | VKTKDGVVEI | TGKHEERQDE | HGYISRCFTR | KYTLPPGVDP |
| 160 | 170 | 180 | 190 | 200 |
| TQVSSSLSPE | GTLTVEAPMP | KLATQSNEIT | IPVTFESRAQ | LGGPEAAKSD |
| 205 | ||||
| ETAAK |
Data source: UniProt
Uniprot Database Entry PhosphoSitePlus ®
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Data source: Panorama
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Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma. Abbatiello SE, Schilling B, Mani DR, Zimmerman LJ, Hall SC, MacLean B, Albertolle M, Allen S, Burgess M, Cusack MP, Gosh M, Hedrick V, Held JM, Inerowicz HD, Jackson A, Keshishian H, Kinsinger CR, Lyssand J, Makowski L, Mesri M, Rodriguez H, Rudnick P, Sadowski P, Sedransk N, Shaddox K, Skates SJ, Kuhn E, Smith D, Whiteaker JR, Whitwell C, Zhang S, Borchers CH, Fisher SJ, Gibson BW, Liebler DC, MacCoss MJ, Neubert TA, Paulovich AG, Regnier FE, Tempst P, Carr SA. Mol Cell Proteomics. 2015 Sep;14(9):2357-74. doi: 10.1074/mcp.M114.047050. Epub 2015 Feb 18. PMID: 25693799
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y8 (1+) | 3.2 | 2.2 | 2.3 | 4.4 | 6.2 | 4 | 5.4 | 6.6 | 4.6 | 15 | 15 | 15 |
| y7 (1+) | 2.5 | 2.5 | 1.8 | 6.4 | 6.5 | 3.6 | 6.9 | 7 | 4 | 15 | 15 | 15 |
| y6 (1+) | 6 | 2.5 | 2 | 11.5 | 5.3 | 3.7 | 13 | 5.9 | 4.2 | 15 | 15 | 15 |
| sum | 3 | 2.1 | 1.8 | 5.3 | 6.2 | 3.7 | 6.1 | 6.5 | 4.1 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma. Abbatiello SE, Schilling B, Mani DR, Zimmerman LJ, Hall SC, MacLean B, Albertolle M, Allen S, Burgess M, Cusack MP, Gosh M, Hedrick V, Held JM, Inerowicz HD, Jackson A, Keshishian H, Kinsinger CR, Lyssand J, Makowski L, Mesri M, Rodriguez H, Rudnick P, Sadowski P, Sedransk N, Shaddox K, Skates SJ, Kuhn E, Smith D, Whiteaker JR, Whitwell C, Zhang S, Borchers CH, Fisher SJ, Gibson BW, Liebler DC, MacCoss MJ, Neubert TA, Paulovich AG, Regnier FE, Tempst P, Carr SA. Mol Cell Proteomics. 2015 Sep;14(9):2357-74. doi: 10.1074/mcp.M114.047050. Epub 2015 Feb 18. PMID: 25693799
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y7 (1+) | 7 | 3.5 | 2.2 | 8.9 | 5.3 | 3.5 | 11.3 | 6.4 | 4.1 | 15 | 15 | 15 |
| y6 (1+) | 1.9 | 1.1 | 1 | 3.6 | 5.3 | 3 | 4.1 | 5.4 | 3.2 | 15 | 15 | 15 |
| y5 (1+) | 2.6 | 1.9 | 1.7 | 3.5 | 5.3 | 3.4 | 4.4 | 5.6 | 3.8 | 15 | 15 | 15 |
| sum | 1.2 | 1.2 | 0.9 | 3.1 | 5.2 | 3 | 3.3 | 5.3 | 3.1 | 15 | 15 | 15 |
Data source: Panorama
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Mol Cell Proteomics. 2016 May;15(5):1622-41. doi: 10.1074/mcp.M116.058354. Epub 2016 Feb 24. Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced Phenotypes. Abelin JG1, Patel J1, Lu X1, Feeney CM1, Fagbami L1, Creech AL1, Hu R1, Lam D1, Davison D1, Pino L1, Qiao JW1, Kuhn E1, Officer A1, Li J2, Abbatiello S1, Subramanian A1, Sidman R2, Snyder E3, Carr SA1, Jaffe JD4.
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Mol Cell Proteomics. 2014 Jul;13(7):1690-704. doi: 10.1074/mcp.M113.036392. Epub 2014 Apr 9. Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mertins P1, Yang F2, Liu T2, Mani DR3, Petyuk VA2, Gillette MA3, Clauser KR3, Qiao JW3, Gritsenko MA2, Moore RJ2, Levine DA4, Townsend R5, Erdmann-Gilmore P5, Snider JE5, Davies SR5, Ruggles KV6, Fenyo D6, Kitchens RT5, Li S5, Olvera N4, Dao F4, Rodriguez H7, Chan DW8, Liebler D9, White F10, Rodland KD2, Mills GB11, Smith RD2, Paulovich AG12, Ellis M5, Carr SA1
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y10 (2+) | 3.4 | 5.6 | 5.6 | 5 | 10.2 | 9 | 6 | 11.6 | 10.6 | 15 | 15 | 15 |
| y12 (2+) | 3.6 | 4.3 | 5.4 | 5 | 9.6 | 9.7 | 6.2 | 10.5 | 11.1 | 15 | 15 | 15 |
| y4 (1+) | 4.6 | 5.4 | 4.2 | 6.3 | 7 | 7 | 7.8 | 8.8 | 8.2 | 15 | 15 | 15 |
| sum | 2.5 | 3 | 4.4 | 4.6 | 7.6 | 7.6 | 5.2 | 8.2 | 8.8 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma. Abbatiello SE, Schilling B, Mani DR, Zimmerman LJ, Hall SC, MacLean B, Albertolle M, Allen S, Burgess M, Cusack MP, Gosh M, Hedrick V, Held JM, Inerowicz HD, Jackson A, Keshishian H, Kinsinger CR, Lyssand J, Makowski L, Mesri M, Rodriguez H, Rudnick P, Sadowski P, Sedransk N, Shaddox K, Skates SJ, Kuhn E, Smith D, Whiteaker JR, Whitwell C, Zhang S, Borchers CH, Fisher SJ, Gibson BW, Liebler DC, MacCoss MJ, Neubert TA, Paulovich AG, Regnier FE, Tempst P, Carr SA. Mol Cell Proteomics. 2015 Sep;14(9):2357-74. doi: 10.1074/mcp.M114.047050. Epub 2015 Feb 18. PMID: 25693799
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y8 (1+) | 3.5 | 2 | 1.6 | 9.4 | 6 | 2.8 | 10 | 6.3 | 3.2 | 15 | 15 | 15 |
| y6 (1+) | 3.8 | 2.6 | 1.2 | 9.6 | 6.7 | 2.5 | 10.3 | 7.2 | 2.8 | 15 | 15 | 15 |
| y5 (1+) | 4.6 | 1.6 | 1.5 | 12.2 | 6.3 | 3.4 | 13 | 6.5 | 3.7 | 15 | 15 | 15 |
| sum | 2.9 | 1.9 | 1.1 | 10.2 | 6.2 | 2.7 | 10.6 | 6.5 | 2.9 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma. Abbatiello SE, Schilling B, Mani DR, Zimmerman LJ, Hall SC, MacLean B, Albertolle M, Allen S, Burgess M, Cusack MP, Gosh M, Hedrick V, Held JM, Inerowicz HD, Jackson A, Keshishian H, Kinsinger CR, Lyssand J, Makowski L, Mesri M, Rodriguez H, Rudnick P, Sadowski P, Sedransk N, Shaddox K, Skates SJ, Kuhn E, Smith D, Whiteaker JR, Whitwell C, Zhang S, Borchers CH, Fisher SJ, Gibson BW, Liebler DC, MacCoss MJ, Neubert TA, Paulovich AG, Regnier FE, Tempst P, Carr SA. Mol Cell Proteomics. 2015 Sep;14(9):2357-74. doi: 10.1074/mcp.M114.047050. Epub 2015 Feb 18. PMID: 25693799
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y7 (1+) | 4.3 | 4.5 | 3.3 | 7.1 | 6.2 | 5.3 | 8.3 | 7.7 | 6.2 | 15 | 15 | 15 |
| y6 (1+) | 3.2 | 4.1 | 1.5 | 5.1 | 5.1 | 3.5 | 6 | 6.5 | 3.8 | 15 | 15 | 15 |
| y8 (1+) | 2.9 | 4 | 2.6 | 5.5 | 5.4 | 5.6 | 6.2 | 6.7 | 6.2 | 15 | 15 | 15 |
| sum | 2.2 | 4 | 2.2 | 5.2 | 5.3 | 4.6 | 5.6 | 6.6 | 5.1 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma. Abbatiello SE, Schilling B, Mani DR, Zimmerman LJ, Hall SC, MacLean B, Albertolle M, Allen S, Burgess M, Cusack MP, Gosh M, Hedrick V, Held JM, Inerowicz HD, Jackson A, Keshishian H, Kinsinger CR, Lyssand J, Makowski L, Mesri M, Rodriguez H, Rudnick P, Sadowski P, Sedransk N, Shaddox K, Skates SJ, Kuhn E, Smith D, Whiteaker JR, Whitwell C, Zhang S, Borchers CH, Fisher SJ, Gibson BW, Liebler DC, MacCoss MJ, Neubert TA, Paulovich AG, Regnier FE, Tempst P, Carr SA. Mol Cell Proteomics. 2015 Sep;14(9):2357-74. doi: 10.1074/mcp.M114.047050. Epub 2015 Feb 18. PMID: 25693799
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y15 (2+) | 5.5 | 7.3 | 5.5 | 15.1 | 9.3 | 7.3 | 16.1 | 11.8 | 9.1 | 15 | 15 | 15 |
| y14 (2+) | 3.7 | 7.4 | 6.6 | 13.6 | 8.6 | 5.8 | 14.1 | 11.3 | 8.8 | 15 | 15 | 15 |
| y13 (2+) | 8.5 | 7.5 | 6.8 | 15.7 | 10.7 | 6.5 | 17.9 | 13.1 | 9.4 | 15 | 15 | 15 |
| sum | 3.7 | 6.3 | 5.8 | 13.5 | 8.8 | 6 | 14 | 10.8 | 8.3 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Anti-peptide monoclonal antibodies generated for immuno-multiple reaction monitoring-mass spectrometry assays have a high probability of supporting Western blot and ELISA. Schoenherr RM, Saul RG, Whiteaker JR, Yan P, Whiteley GR, Paulovich AG. Mol Cell Proteomics. 2015 Feb;14(2):382-98. doi: 10.1074/mcp.O114.043133. Epub 2014 Dec 15. PMID: 25512614
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y4 (1+) | 25 | 9 | 1.6 | 28.8 | 10.3 | 3.1 | 38.1 | 13.7 | 3.5 | 15 | 15 | 15 |
| y5 (1+) | 13.5 | 3.2 | 0.8 | 16.4 | 4 | 2.9 | 21.2 | 5.1 | 3 | 15 | 15 | 15 |
| y6 (1+) | 14.9 | 2.1 | 1.5 | 17.6 | 3.8 | 2.6 | 23.1 | 4.3 | 3 | 15 | 15 | 15 |
| sum | 13.4 | 1.8 | 1 | 16 | 3.5 | 2.5 | 20.9 | 3.9 | 2.7 | 15 | 15 | 15 |
Data source: Panorama
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Kennedy JJ, Yan P, Zhao L, Ivey RG, Voytovich U, Moore HD, Lin C, Pogosova-Agadjanyan EL, Stirewalt DL, Reding KW, Whiteaker JR, Paulovich AG. Immobilized metal affinity chromatography coupled to multiple reaction monitoring enables reproducible quantification of phospho-signaling. Molecular and Cellular Proteomics. mcp.O115.054940
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| b5 (1+) | 30.4 | 6.5 | 3.9 | 24.4 | 8.5 | 7.6 | 39 | 10.7 | 8.5 | 15 | 24 | 15 |
| y4 (1+) | 29.5 | 6.1 | 5.2 | 22.2 | 7.7 | 8.5 | 36.9 | 9.8 | 10 | 15 | 24 | 15 |
| y5 (1+) | 26.3 | 7 | 7.3 | 28.6 | 9.7 | 12 | 38.9 | 12 | 14 | 15 | 24 | 15 |
| sum | 28.1 | 6.2 | 5.1 | 24.2 | 7.2 | 8.5 | 37.1 | 9.5 | 9.9 | 15 | 24 | 15 |
Data source: Panorama
View Details (opens in a new window)
Anti-peptide monoclonal antibodies generated for immuno-multiple reaction monitoring-mass spectrometry assays have a high probability of supporting Western blot and ELISA. Schoenherr RM, Saul RG, Whiteaker JR, Yan P, Whiteley GR, Paulovich AG. Mol Cell Proteomics. 2015 Feb;14(2):382-98. doi: 10.1074/mcp.O114.043133. Epub 2014 Dec 15. PMID: 25512614
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y5 (1+) | 18.5 | 3.8 | 3.4 | 22.3 | 4.3 | 5.8 | 29 | 5.7 | 6.7 | 15 | 15 | 15 |
| y6 (1+) | 22.3 | 3.5 | 2.9 | 20.9 | 5.9 | 6.8 | 30.6 | 6.9 | 7.4 | 15 | 15 | 15 |
| y8 (1+) | 20.1 | 6 | 8.1 | 21.7 | 13.6 | 9.5 | 29.6 | 14.9 | 12.5 | 15 | 15 | 15 |
| sum | 13.1 | 2.9 | 3 | 18.1 | 7.6 | 6.2 | 22.3 | 8.1 | 6.9 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Anti-peptide monoclonal antibodies generated for immuno-multiple reaction monitoring-mass spectrometry assays have a high probability of supporting Western blot and ELISA. Schoenherr RM, Saul RG, Whiteaker JR, Yan P, Whiteley GR, Paulovich AG. Mol Cell Proteomics. 2015 Feb;14(2):382-98. doi: 10.1074/mcp.O114.043133. Epub 2014 Dec 15. PMID: 25512614
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y13 (2+) | 29.1 | 16.5 | 7.2 | 36.9 | 20.4 | 11.5 | 47 | 26.2 | 13.6 | 15 | 15 | 15 |
| y14 (2+) | 18 | 15.6 | 11.4 | 26.1 | 20.8 | 18.4 | 31.7 | 26 | 21.6 | 15 | 15 | 15 |
| y15 (2+) | 15.1 | 8.9 | 14.9 | 18.3 | 13 | 17.9 | 23.7 | 15.8 | 23.3 | 15 | 15 | 15 |
| sum | 16.4 | 8.7 | 8.9 | 17.6 | 13.3 | 13.4 | 24.1 | 15.9 | 16.1 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
mTORC1-driven protein translation correlates with clinical benefit of capivasertib within a genetically preselected cohort of PIK3CA-altered tumours. Constance A Sobsey, Bjoern C Froehlich, Georgia Mitsa, Sahar Ibrahim, Robert Popp, Rene P Zahedi, Elza C de Bruin, Christoph H Borchers, Gerald Batist
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y5 (1+) | 17 | 5 | 5.3 | 22.4 | 5.2 | 5 | 28.1 | 7.2 | 7.3 | 15 | 16 | 17 |
| y13 (2+) | 18.3 | 5.8 | 5.9 | 22.3 | 5.2 | 4.9 | 28.8 | 7.8 | 7.7 | 15 | 16 | 17 |
| y14 (2+) | 16.9 | 5.6 | 3 | 23.1 | 6.1 | 5.2 | 28.6 | 8.3 | 6 | 15 | 16 | 17 |
| y15 (2+) | 16.1 | 4.3 | 4.3 | 20.6 | 6 | 4 | 26.1 | 7.4 | 5.9 | 15 | 16 | 17 |
| y7 (2+) | 20.2 | 7.3 | 4.6 | 25.2 | 8.1 | 6 | 32.3 | 10.9 | 7.6 | 15 | 16 | 17 |
| sum | 14.9 | 1.9 | 1.6 | 19.7 | 3 | 1.8 | 24.7 | 3.6 | 2.4 | 15 | 16 | 17 |
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