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Overview Data source: UniProt

Official Gene Symbol Other Aliases
IGFALS ALS
Sequence Length (AA) Molecular Weight (Da)
605 66035
Protein Name
Insulin-like growth factor-binding protein complex acid labile subunit
Sources
UniProt
PhosphoSitePlus ®
GeneCards
Human Protein Atlas

Protein Sequence hover to view complete sequence

10 20 30 40 50
MALRKGGLAL ALLLLSWVAL GPRSLEGADP GTPGEAEGPA CPAACVCSYD
60 70 80 90 100
DDADELSVFC SSRNLTRLPD GVPGGTQALW LDGNNLSSVP PAAFQNLSSL
110 120 130 140 150
GFLNLQGGQL GSLEPQALLG LENLCHLHLE RNQLRSLALG TFAHTPALAS
160 170 180 190 200
LGLSNNRLSR LEDGLFEGLG SLWDLNLGWN SLAVLPDAAF RGLGSLRELV
210 220 230 240 250
LAGNRLAYLQ PALFSGLAEL RELDLSRNAL RAIKANVFVQ LPRLQKLYLD
260 270 280 290 300
RNLIAAVAPG AFLGLKALRW LDLSHNRVAG LLEDTFPGLL GLRVLRLSHN
310 320 330 340 350
AIASLRPRTF KDLHFLEELQ LGHNRIRQLA ERSFEGLGQL EVLTLDHNQL
360 370 380 390 400
QEVKAGAFLG LTNVAVMNLS GNCLRNLPEQ VFRGLGKLHS LHLEGSCLGR
410 420 430 440 450
IRPHTFTGLS GLRRLFLKDN GLVGIEEQSL WGLAELLELD LTSNQLTHLP
460 470 480 490 500
HRLFQGLGKL EYLLLSRNRL AELPADALGP LQRAFWLDVS HNRLEALPNS
510 520 530 540 550
LLAPLGRLRY LSLRNNSLRT FTPQPPGLER LWLEGNPWDC GCPLKALRDF
560 570 580 590 600
ALQNPSAVPR FVQAICEGDD CQPPAYTYNN ITCASPPEVV GLDLRDLSEA
605
HFAPC

Data source: UniProt


Position of Targeted Peptide Analytes Relative to SNPs, Isoforms, and PTMs

Uniprot Database Entry PhosphoSitePlus ®

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Phosphorylation Acetylation Ubiquitylation Other

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Assay Details for non-CPTAC-2678 Collapse assay details

Data source: Panorama

Official Gene Symbol
IGFALS
Peptide Sequence
SLALGTFAHTPALASLGLSNNR
Modification Type
unmodified
Protein - Site of Modification
N/A
Peptide - Site of Modification
N/A
Peptide Start
136
Peptide End
157
CPTAC ID
non-CPTAC-2678
Peptide Molecular Mass
2,210.1808
Species
Homo sapiens (Human)
Assay Type
Direct MRM
Matrix
plasma
Submitting Laboratory
UVic-Genome BC Proteomics Centre
Submitting Lab PI
Christoph Borchers

Assay Parameters Collapse assay parameters

Data source: Panorama

Instrument
6490 Triple Quad (Agilent)
Internal Standard
synthetic peptide
Peptide Standard Purity
>95%
Peptide Standard Label Type
13C and 15N at C-terminus R
LC
1290 LC (Agilent)
Column Packing
Zorbax Eclipse Plus C18, 1.8 µm
Column Dimensions
2.1 x 150 mm
Flow Rate
400 µL/min

Chromatograms

Data source: Panorama


Response Curves

Data source: Panorama

Retrieving Data

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Repeatability

Data source: Panorama

  Average intra-assay CV
(within day CV)
Average inter-assay CV
(between day CV)
Total CV
equation
n=
Fragment ion / Transition Low Med High Low Med High Low Med High Low Med High
y6 (1+) 5.4 4.7 16.9 19.1 7.8 23.7 19.8 9.1 29.1 15 15 15
b2 (1+) 5.8 4.2 10 18.7 7.3 13.2 19.6 8.4 16.6 15 15 15
b14 (2+) 9.2 5.2 14 18.3 8 19.6 20.5 9.5 24.1 15 15 15
b6 (2+) 7 4.3 12.1 18.7 7.1 15.3 20 8.3 19.5 15 15 15
b17 (2+) 5.7 4.4 16.8 20.1 8.6 22.8 20.9 9.7 28.3 15 15 15
sum 5.7 4.3 13.7 18.9 7.4 18.3 19.7 8.6 22.9 15 15 15

Additional Resources and Comments