| Official Gene Symbol | Other Aliases |
|---|---|
| LMNA | LMN1 |
| Sequence Length (AA) | Molecular Weight (Da) |
|---|---|
| 664 | 74139 |
| Protein Name |
|---|
| Prelamin-A/C |
| Sources | |
|---|---|
|
UniProt PhosphoSitePlus ® GeneCards |
Human Protein Atlas |
| 10 | 20 | 30 | 40 | 50 |
| METPSQRRAT | RSGAQASSTP | LSPTRITRLQ | EKEDLQELND | RLAVYIDRVR |
| 60 | 70 | 80 | 90 | 100 |
| SLETENAGLR | LRITESEEVV | SREVSGIKAA | YEAELGDARK | TLDSVAKERA |
| 110 | 120 | 130 | 140 | 150 |
| RLQLELSKVR | EEFKELKARN | TKKEGDLIAA | QARLKDLEAL | LNSKEAALST |
| 160 | 170 | 180 | 190 | 200 |
| ALSEKRTLEG | ELHDLRGQVA | KLEAALGEAK | KQLQDEMLRR | VDAENRLQTM |
| 210 | 220 | 230 | 240 | 250 |
| KEELDFQKNI | YSEELRETKR | RHETRLVEID | NGKQREFESR | LADALQELRA |
| 260 | 270 | 280 | 290 | 300 |
| QHEDQVEQYK | KELEKTYSAK | LDNARQSAER | NSNLVGAAHE | ELQQSRIRID |
| 310 | 320 | 330 | 340 | 350 |
| SLSAQLSQLQ | KQLAAKEAKL | RDLEDSLARE | RDTSRRLLAE | KEREMAEMRA |
| 360 | 370 | 380 | 390 | 400 |
| RMQQQLDEYQ | ELLDIKLALD | MEIHAYRKLL | EGEEERLRLS | PSPTSQRSRG |
| 410 | 420 | 430 | 440 | 450 |
| RASSHSSQTQ | GGGSVTKKRK | LESTESRSSF | SQHARTSGRV | AVEEVDEEGK |
| 460 | 470 | 480 | 490 | 500 |
| FVRLRNKSNE | DQSMGNWQIK | RQNGDDPLLT | YRFPPKFTLK | AGQVVTIWAA |
| 510 | 520 | 530 | 540 | 550 |
| GAGATHSPPT | DLVWKAQNTW | GCGNSLRTAL | INSTGEEVAM | RKLVRSVTVV |
| 560 | 570 | 580 | 590 | 600 |
| EDDEDEDGDD | LLHHHHGSHC | SSSGDPAEYN | LRSRTVLCGT | CGQPADKASA |
| 610 | 620 | 630 | 640 | 650 |
| SGSGAQVGGP | ISSGSSASSV | TVTRSYRSVG | GSGGGSFGDN | LVTRSYLLGN |
| 660 | 664 | |||
| SSPRTQSPQN | CSIM |
Data source: UniProt
Uniprot Database Entry PhosphoSitePlus ®
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Data source: Panorama
View Details (opens in a new window)
Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins. Kennedy JJ, Abbatiello SE, Kim K, Yan P, Whiteaker JR, Lin C, Kim JS, Zhang Y, Wang X, Ivey RG, Zhao L, Min H, Lee Y, Yu MH, Yang EG, Lee C, Wang P, Rodriguez H, Kim Y, Carr SA, Paulovich AG. Nat Methods. 2014 Feb;11(2):149-55. doi: 10.1038/nmeth.2763. Epub 2013 Dec 8. PMID: 24317253
Response curves acquired at Broad Institute. Repeatability data acquired at Fred Hutchinson Cancer Research Center.
Response curves acquired at Broad Institute. Repeatability data acquired at Fred Hutchinson Cancer Research Center.
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y8 (1+) | 8 | 6.2 | 4.4 | 17.6 | 10.2 | 6.4 | 19.3 | 11.9 | 7.8 | 15 | 25 | 15 |
| y7 (1+) | 7.8 | 5.3 | 3.6 | 13 | 10.3 | 6.3 | 15.2 | 11.6 | 7.3 | 15 | 25 | 15 |
| y6 (1+) | 15.3 | 5.2 | 3.5 | 21.2 | 10.3 | 6.2 | 26.1 | 11.5 | 7.1 | 15 | 25 | 15 |
| sum | 4.7 | 5 | 3.1 | 12.8 | 10 | 5.7 | 13.6 | 11.2 | 6.5 | 15 | 25 | 15 |
Data source: Panorama
View Details (opens in a new window)
Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins. Kennedy JJ, Abbatiello SE, Kim K, Yan P, Whiteaker JR, Lin C, Kim JS, Zhang Y, Wang X, Ivey RG, Zhao L, Min H, Lee Y, Yu MH, Yang EG, Lee C, Wang P, Rodriguez H, Kim Y, Carr SA, Paulovich AG. Nat Methods. 2014 Feb;11(2):149-55. doi: 10.1038/nmeth.2763. Epub 2013 Dec 8. PMID: 24317253
Response curves acquired at Broad Institute. Repeatability data acquired at Fred Hutchinson Cancer Research Center.
Response curves acquired at Broad Institute. Repeatability data acquired at Fred Hutchinson Cancer Research Center.
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y22 (2+) | 8.7 | 6.9 | 6.7 | 11.9 | 12.1 | 21 | 14.7 | 13.9 | 22 | 25 | 15 | 15 |
| y21 (2+) | 8.9 | 4.7 | 3.5 | 13.6 | 10.5 | 13.6 | 16.3 | 11.5 | 14 | 25 | 15 | 15 |
| y20 (2+) | 8.6 | 5.5 | 5 | 13.2 | 8.3 | 13.9 | 15.8 | 10 | 14.8 | 25 | 15 | 15 |
| sum | 7.4 | 4.6 | 4.1 | 12.5 | 9.2 | 14.3 | 14.5 | 10.3 | 14.9 | 25 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Kennedy JJ, Yan P, Zhao L, Ivey RG, Voytovich U, Moore HD, Lin C, Pogosova-Agadjanyan EL, Stirewalt DL, Reding KW, Whiteaker JR, Paulovich AG. Immobilized metal affinity chromatography coupled to multiple reaction monitoring enables reproducible quantification of phospho-signaling. Molecular and Cellular Proteomics. mcp.O115.054940
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y15 (2+) | 34.4 | 37.5 | 26.3 | 29 | 50.3 | 26.8 | 45 | 62.7 | 37.5 | 11 | 15 | 12 |
| y8 (1+) | 33.4 | 21.6 | 21.7 | 35.1 | 27.5 | 10.8 | 48.5 | 35 | 24.2 | 11 | 15 | 12 |
| y11 (1+) | 26.3 | 18.8 | 24.6 | 22.8 | 25.4 | 29.8 | 34.8 | 31.6 | 38.6 | 11 | 15 | 12 |
| sum | 30.3 | 9.6 | 13.9 | 20.7 | 18.6 | 13.4 | 36.7 | 20.9 | 19.3 | 11 | 15 | 12 |
Data source: Panorama
View Details (opens in a new window)
Kennedy JJ, Yan P, Zhao L, Ivey RG, Voytovich U, Moore HD, Lin C, Pogosova-Agadjanyan EL, Stirewalt DL, Reding KW, Whiteaker JR, Paulovich AG. Immobilized metal affinity chromatography coupled to multiple reaction monitoring enables reproducible quantification of phospho-signaling. Molecular and Cellular Proteomics. mcp.O115.054940
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y15 (2+) | 35.6 | 31.5 | 35.8 | 43.9 | 34.5 | 30.3 | 56.5 | 46.7 | 46.9 | 11 | 22 | 14 |
| y8 (1+) | 35 | 12.9 | 17.9 | 28.9 | 16 | 16.6 | 45.4 | 20.6 | 24.4 | 11 | 22 | 14 |
| y11 (1+) | 41.9 | 26 | 14 | 46.2 | 33.9 | 18.9 | 62.4 | 42.7 | 23.5 | 11 | 22 | 14 |
| sum | 28.1 | 13.2 | 15.6 | 21.9 | 14.3 | 14.3 | 35.6 | 19.5 | 21.2 | 11 | 22 | 14 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| b3 (1+) | 11.5 | 12.7 | 6.2 | 12.6 | 11.9 | 10.3 | 17.1 | 17.4 | 12 | 15 | 15 | 15 |
| y4 (1+) | 11.6 | 6.6 | 4.8 | 10.4 | 9.7 | 7.9 | 15.6 | 11.7 | 9.2 | 15 | 15 | 15 |
| y5 (1+) | 10.9 | 12.5 | 6.7 | 15.2 | 13.3 | 8.8 | 18.7 | 18.3 | 11.1 | 15 | 15 | 15 |
| y7 (1+) | 12 | 8.2 | 7.1 | 13.5 | 7.5 | 10.3 | 18.1 | 11.1 | 12.5 | 15 | 15 | 15 |
| y8 (1+) | 15.4 | 10.2 | 5 | 15.8 | 16.3 | 10 | 22.1 | 19.2 | 11.2 | 15 | 15 | 15 |
| sum | 6.8 | 3.2 | 2.6 | 7.4 | 4.9 | 7.3 | 10 | 5.9 | 7.7 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Molecular phenotyping of laboratory mouse strains using 500 multiple reaction monitoring mass spectrometry plasma assays. Michaud SA, Sinclair NJ, Petrošová H, Palmer AL, Pistawka AJ, Zhang S, Hardie DB, Mohammed Y Eshghi A1, Richard VR, Sickmann A, Borchers CH. Commun Biol. 2018 Jun 27;1:78. doi: 10.1038/s42003-018-0087-6. eCollection 2018.
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y2 (1+) | 8.9 | 4.4 | 9.6 | 8.7 | 8 | 10.7 | 12.4 | 9.1 | 14.4 | 15 | 15 | 15 |
| b2 (1+) | 9.2 | 9.6 | 4.4 | 16.2 | 11.9 | 6.8 | 18.6 | 15.3 | 8.1 | 15 | 15 | 15 |
| y7 (2+) | 20.2 | 5.6 | 7.6 | 19.2 | 10.1 | 7.7 | 27.9 | 11.5 | 10.8 | 15 | 15 | 15 |
| y8 (2+) | 10.5 | 5.5 | 6.5 | 11 | 7.8 | 7.3 | 15.2 | 9.5 | 9.8 | 15 | 15 | 15 |
| y9 (2+) | 14.2 | 8.1 | 9.8 | 17.9 | 10.3 | 9.6 | 22.8 | 13.1 | 13.7 | 15 | 15 | 15 |
| sum | 5.8 | 3.4 | 3.7 | 7.7 | 6.6 | 5.8 | 9.6 | 7.4 | 6.9 | 15 | 15 | 15 |
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