| Official Gene Symbol | Other Aliases |
|---|---|
| CDK1 | CDC2, CDC28A, CDKN1, P34CDC2 |
| Sequence Length (AA) | Molecular Weight (Da) |
|---|---|
| 297 | 34095 |
| Protein Name |
|---|
| Cyclin-dependent kinase 1 |
| Sources | |
|---|---|
|
UniProt PhosphoSitePlus ® GeneCards |
Human Protein Atlas |
| 10 | 20 | 30 | 40 | 50 |
| MEDYTKIEKI | GEGTYGVVYK | GRHKTTGQVV | AMKKIRLESE | EEGVPSTAIR |
| 60 | 70 | 80 | 90 | 100 |
| EISLLKELRH | PNIVSLQDVL | MQDSRLYLIF | EFLSMDLKKY | LDSIPPGQYM |
| 110 | 120 | 130 | 140 | 150 |
| DSSLVKSYLY | QILQGIVFCH | SRRVLHRDLK | PQNLLIDDKG | TIKLADFGLA |
| 160 | 170 | 180 | 190 | 200 |
| RAFGIPIRVY | THEVVTLWYR | SPEVLLGSAR | YSTPVDIWSI | GTIFAELATK |
| 210 | 220 | 230 | 240 | 250 |
| KPLFHGDSEI | DQLFRIFRAL | GTPNNEVWPE | VESLQDYKNT | FPKWKPGSLA |
| 260 | 270 | 280 | 290 | 297 |
| SHVKNLDENG | LDLLSKMLIY | DPAKRISGKM | ALNHPYFNDL | DNQIKKM |
Data source: UniProt
Uniprot Database Entry PhosphoSitePlus ®
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Data source: Panorama
View Details (opens in a new window)
Targeted Mass Spectrometry Enables Quantification of Novel Pharmacodynamic Biomarkers of ATM Kinase Inhibition. Whiteaker JR, Wang T, Zhao L, Schoenherr RM, Kennedy JJ, Voytovich U, Ivey RG, Huang D, Lin C, Colantonio S, Caceres TW, Roberts RR, Knotts JG, Kaczmarczyk JA, Blonder J, Reading JJ, Richardson CW, Hewitt SM, Garcia-Buntley SS, Bocik W, Hiltke T, Rodriguez H, Harrington EA, Barrett JC, Lombardi B, Marco-Casanova P, Pierce AJ, Paulovich AG. Cancers (Basel). 2021 Jul 30;13(15):3843. doi: 10.3390/cancers13153843. PMID: 34359745
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y4 (1+) | 24.9 | 11.3 | 7.9 | 24.6 | 21.2 | 7.5 | 35 | 24 | 10.9 | 15 | 27 | 15 |
| b7 (1+) | 25.3 | 13.3 | 5.9 | 31.5 | 24.9 | 9.1 | 40.4 | 28.2 | 10.8 | 15 | 27 | 15 |
| b6 (1+) | 13.9 | 15 | 9 | 30.7 | 21.9 | 9.1 | 33.7 | 26.5 | 12.8 | 15 | 27 | 15 |
| y10 (2+) | 31.5 | 14.7 | 9.8 | 37.3 | 25.8 | 6.5 | 48.8 | 29.7 | 11.8 | 15 | 27 | 15 |
| y11 (2+) | 20.5 | 13.4 | 12 | 24.6 | 22.1 | 8.5 | 32 | 25.8 | 14.7 | 15 | 27 | 15 |
| y3 (1+) | 18.2 | 9.3 | 8 | 17.6 | 18.7 | 8.4 | 25.3 | 20.9 | 11.6 | 15 | 27 | 15 |
| y5 (1+) | 20.7 | 12.5 | 8 | 20 | 18.4 | 8.7 | 28.8 | 22.2 | 11.8 | 15 | 27 | 15 |
| sum | 11.8 | 9.3 | 7.7 | 13.7 | 19.8 | 6.9 | 18.1 | 21.9 | 10.3 | 15 | 27 | 15 |
Data source: Panorama
View Details (opens in a new window)
Targeted Mass Spectrometry Enables Quantification of Novel Pharmacodynamic Biomarkers of ATM Kinase Inhibition. Whiteaker JR, Wang T, Zhao L, Schoenherr RM, Kennedy JJ, Voytovich U, Ivey RG, Huang D, Lin C, Colantonio S, Caceres TW, Roberts RR, Knotts JG, Kaczmarczyk JA, Blonder J, Reading JJ, Richardson CW, Hewitt SM, Garcia-Buntley SS, Bocik W, Hiltke T, Rodriguez H, Harrington EA, Barrett JC, Lombardi B, Marco-Casanova P, Pierce AJ, Paulovich AG. Cancers (Basel). 2021 Jul 30;13(15):3843. doi: 10.3390/cancers13153843. PMID: 34359745
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| b7 (2+) | 15.3 | 8.7 | 5.4 | 24.1 | 19.6 | 5.7 | 28.5 | 21.4 | 7.9 | 15 | 27 | 15 |
| b7 (1+) | 18.8 | 9.4 | 5.1 | 19.2 | 19.2 | 7.1 | 26.9 | 21.4 | 8.7 | 15 | 27 | 15 |
| b6 (1+) | 17.9 | 8.6 | 4 | 17 | 21.2 | 6.3 | 24.7 | 22.9 | 7.5 | 15 | 27 | 15 |
| y3 (1+) | 10.9 | 6.6 | 4.5 | 14.1 | 19.4 | 10 | 17.8 | 20.5 | 11 | 15 | 27 | 15 |
| y4 (1+) | 16.8 | 9.9 | 5.2 | 18.9 | 19 | 8 | 25.3 | 21.4 | 9.5 | 15 | 27 | 15 |
| y5 (1+) | 14.4 | 6.9 | 4.1 | 17.3 | 17.1 | 9.4 | 22.5 | 18.4 | 10.3 | 15 | 27 | 15 |
| y6 (1+) | 23.9 | 8.9 | 4.4 | 23.9 | 14.8 | 7.7 | 33.8 | 17.3 | 8.9 | 15 | 27 | 15 |
| sum | 7.4 | 5.5 | 2.8 | 10.1 | 17.9 | 7 | 12.5 | 18.7 | 7.5 | 15 | 27 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y6 (1+) | 18 | 6.7 | 4.4 | 22 | 7.1 | 5.6 | 28.4 | 9.8 | 7.1 | 15 | 15 | 15 |
| y8 (1+) | 27.4 | 8.4 | 3.3 | 30.3 | 13.3 | 3.6 | 40.9 | 15.7 | 4.9 | 15 | 15 | 15 |
| y9 (1+) | 35.3 | 12.9 | 6.6 | 48.6 | 13.3 | 9.5 | 60.1 | 18.5 | 11.6 | 15 | 15 | 15 |
| sum | 14.3 | 5.1 | 3.3 | 20.9 | 7.1 | 4.2 | 25.3 | 8.7 | 5.3 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y3 (1+) | 14.8 | 8.2 | 10.4 | 16.1 | 12.1 | 10.2 | 21.9 | 14.6 | 14.6 | 15 | 15 | 15 |
| y5 (1+) | 15.7 | 15.6 | 7.5 | 18.9 | 15.3 | 7.6 | 24.6 | 21.9 | 10.7 | 15 | 15 | 15 |
| y6 (1+) | 15.2 | 12.9 | 15 | 15.9 | 12.6 | 13.3 | 22 | 18 | 20 | 15 | 15 | 15 |
| y7 (1+) | 32.8 | 18.3 | 9.5 | 31.7 | 18.7 | 14.7 | 45.6 | 26.2 | 17.5 | 15 | 15 | 15 |
| y8 (1+) | 16.1 | 6.7 | 6.6 | 11.4 | 13 | 7.4 | 19.7 | 14.6 | 9.9 | 15 | 15 | 15 |
| y10 (1+) | 19.3 | 10.4 | 5.8 | 21.1 | 10.5 | 7.2 | 28.6 | 14.8 | 9.2 | 15 | 15 | 15 |
| sum | 7.4 | 4.1 | 5.6 | 7.7 | 5.6 | 6.1 | 10.7 | 6.9 | 8.3 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y3 (1+) | 11.7 | 4.8 | 3.8 | 10.4 | 4.4 | 3.6 | 15.7 | 6.5 | 5.2 | 15 | 15 | 15 |
| y4 (1+) | 18.1 | 11.4 | 10.2 | 23.6 | 13.5 | 12.4 | 29.7 | 17.7 | 16.1 | 15 | 15 | 15 |
| y5 (1+) | 10.7 | 4.2 | 5.7 | 10.6 | 4.6 | 5.3 | 15.1 | 6.2 | 7.8 | 15 | 15 | 15 |
| y6 (1+) | 10.5 | 9.9 | 8.7 | 11.4 | 12.8 | 9 | 15.5 | 16.2 | 12.5 | 15 | 15 | 15 |
| y7 (1+) | 21.6 | 11.6 | 19.3 | 24.7 | 11.9 | 14.9 | 32.8 | 16.6 | 24.4 | 15 | 15 | 15 |
| y8 (1+) | 11.9 | 5.2 | 8.2 | 12.9 | 6.4 | 8.3 | 17.6 | 8.2 | 11.7 | 15 | 15 | 15 |
| y9 (1+) | 11.7 | 8.7 | 9.4 | 12.6 | 10.5 | 9.4 | 17.2 | 13.6 | 13.3 | 15 | 15 | 15 |
| y10 (1+) | 9.6 | 5.4 | 3.3 | 12.2 | 4.9 | 3.2 | 15.5 | 7.3 | 4.6 | 15 | 15 | 15 |
| sum | 5.3 | 3.1 | 3.3 | 6.6 | 2.4 | 3.1 | 8.5 | 3.9 | 4.5 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y6 (1+) | 37.4 | 40.1 | 55.9 | 51.1 | 37.4 | 83 | 63.3 | 54.8 | 100.1 | 15 | 15 | 15 |
| y5 (1+) | 19.1 | 9.8 | 6.8 | 20.7 | 11.1 | 7.8 | 28.2 | 14.8 | 10.3 | 15 | 15 | 15 |
| y4 (1+) | 25.1 | 15.9 | 7.5 | 27.2 | 16 | 15.9 | 37 | 22.6 | 17.6 | 15 | 15 | 15 |
| sum | 14.3 | 8.8 | 4.8 | 14.8 | 9.3 | 7.1 | 20.6 | 12.8 | 8.6 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y3 (1+) | 12.3 | 4.4 | 4 | 10.3 | 4.7 | 4 | 16 | 6.4 | 5.7 | 15 | 15 | 15 |
| y6 (1+) | 10.5 | 12.1 | 11.1 | 9.2 | 12.8 | 11.5 | 14 | 17.6 | 16 | 15 | 15 | 15 |
| y7 (1+) | 11.6 | 5.9 | 9.2 | 16.3 | 6.9 | 10.9 | 20 | 9.1 | 14.3 | 15 | 15 | 15 |
| y8 (1+) | 9.4 | 6.5 | 11.4 | 10.5 | 9.6 | 11.3 | 14.1 | 11.6 | 16.1 | 15 | 15 | 15 |
| b6 (1+) | 8.4 | 9 | 8.6 | 15.6 | 9.6 | 9.8 | 17.7 | 13.2 | 13 | 15 | 15 | 15 |
| b5 (1+) | 12.4 | 4.8 | 5.7 | 12.4 | 4.9 | 6.1 | 17.5 | 6.9 | 8.3 | 15 | 15 | 15 |
| sum | 5.7 | 3.3 | 2.2 | 5 | 3 | 2.1 | 7.6 | 4.5 | 3 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y5 (1+) | 44.3 | 9.7 | 12.6 | 56.2 | 5.7 | 11.2 | 71.6 | 11.3 | 16.9 | 15 | 15 | 15 |
| y4 (1+) | 34.5 | 16.6 | 16.6 | 41.1 | 15.3 | 12.5 | 53.7 | 22.6 | 20.8 | 15 | 15 | 15 |
| y3 (1+) | 19 | 14.5 | 14.8 | 32.3 | 13.5 | 14.8 | 37.5 | 19.8 | 20.9 | 15 | 15 | 15 |
| sum | 23.1 | 8.6 | 7.1 | 28.7 | 7.4 | 7.2 | 36.8 | 11.3 | 10.1 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y5 (1+) | 39.6 | 11.5 | 13.3 | 45.8 | 14 | 18.3 | 60.5 | 18.1 | 22.6 | 15 | 15 | 15 |
| y4 (1+) | 36.1 | 33.7 | 12.7 | 55.1 | 33.9 | 12.2 | 65.9 | 47.8 | 17.6 | 15 | 15 | 15 |
| y3 (1+) | 48 | 17.5 | 14.3 | 45.8 | 20.1 | 16.2 | 66.3 | 26.7 | 21.6 | 15 | 15 | 15 |
| sum | 18.2 | 12.2 | 7.8 | 27.2 | 12.6 | 11.7 | 32.7 | 17.5 | 14.1 | 15 | 15 | 15 |
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