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Overview Data source: UniProt

Official Gene Symbol Other Aliases
FGFR1 BFGFR,CEK,FGFBR,FLG,FLT2,HBGFR
Sequence Length (AA) Molecular Weight (Da)
822 91868
Protein Name
Fibroblast growth factor receptor 1
Sources
UniProt
PhosphoSitePlus ®
GeneCards
Human Protein Atlas

Protein Sequence hover to view complete sequence

10 20 30 40 50
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL
60 70 80 90 100
LQLRCRLRDD VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA
110 120 130 140 150
CVTSSPSGSD TTYFSVNVSD ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP
160 170 180 190 200
VAPYWTSPEK MEKKLHAVPA AKTVKFKCPS SGTPNPTLRW LKNGKEFKPD
210 220 230 240 250
HRIGGYKVRY ATWSIIMDSV VPSDKGNYTC IVENEYGSIN HTYQLDVVER
260 270 280 290 300
SPHRPILQAG LPANKTVALG SNVEFMCKVY SDPQPHIQWL KHIEVNGSKI
310 320 330 340 350
GPDNLPYVQI LKTAGVNTTD KEMEVLHLRN VSFEDAGEYT CLAGNSIGLS
360 370 380 390 400
HHSAWLTVLE ALEERPAVMT SPLYLEIIIY CTGAFLISCM VGSVIVYKMK
410 420 430 440 450
SGTKKSDFHS QMAVHKLAKS IPLRRQVTVS ADSSASMNSG VLLVRPSRLS
460 470 480 490 500
SSGTPMLAGV SEYELPEDPR WELPRDRLVL GKPLGEGCFG QVVLAEAIGL
510 520 530 540 550
DKDKPNRVTK VAVKMLKSDA TEKDLSDLIS EMEMMKMIGK HKNIINLLGA
560 570 580 590 600
CTQDGPLYVI VEYASKGNLR EYLQARRPPG LEYCYNPSHN PEEQLSSKDL
610 620 630 640 650
VSCAYQVARG MEYLASKKCI HRDLAARNVL VTEDNVMKIA DFGLARDIHH
660 670 680 690 700
IDYYKKTTNG RLPVKWMAPE ALFDRIYTHQ SDVWSFGVLL WEIFTLGGSP
710 720 730 740 750
YPGVPVEELF KLLKEGHRMD KPSNCTNELY MMMRDCWHAV PSQRPTFKQL
760 770 780 790 800
VEDLDRIVAL TSNQEYLDLS MPLDQYSPSF PDTRSSTCSS GEDSVFSHEP
810 820 822
LPEEPCLPRH PAQLANGGLK RR

Data source: UniProt


Position of Targeted Peptide Analytes Relative to SNPs, Isoforms, and PTMs

Uniprot Database Entry PhosphoSitePlus ®

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Phosphorylation Acetylation Ubiquitylation Other

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Assay Details for CPTAC-1773 Collapse assay details

Data source: Panorama

Official Gene Symbol
FGFR1
Peptide Modified Sequence
DIHHIDY[+80.0]YK
Modification Type
Phospho (Y)
Protein - Site of Modification
653
Peptide - Site of Modification
7
Peptide Start
647
Peptide End
655
CPTAC ID
CPTAC-1773
Peptide Molecular Mass
1,282.5384
Species
Homo sapiens (Human)
Assay Type
Direct PRM
Matrix
E.coli Lysate
Submitting Laboratory
Johns Hopkins University / Pandey
Submitting Lab PI
Akhilesh Pandey

Assay Parameters Collapse assay parameters Test button response curves

Data source: Panorama

Instrument
Orbitrap Fusion Lumos
Internal Standard
100fmol
Peptide Standard Purity
>80%
Peptide Standard Label Type
13C and 15N at C-terminus K
LC
Easy nLC 1200 System
Column Packing
C18 2um 100A
Column Dimensions
75um i.d. x 50cm
Flow Rate
300nl/min

Chromatograms

Data source: Panorama


Response Curves

Data source: Panorama

Retrieving Data

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Repeatability

Data source: Panorama

  Average intra-assay CV
(within day CV)
Average inter-assay CV
(between day CV)
Total CV
equation
n=
Fragment ion / Transition Low Med High Low Med High Low Med High Low Med High
b4 (1+) 10.8 10.2 6.9 9.2 8.6 11.3 14.2 13.3 13.2 15 15 15
b3 (1+) 8.8 6.9 7.6 10 6.5 12.8 13.3 9.5 14.9 15 15 15
y3 (1+) 10.8 6.2 9 13.1 6.3 12.2 17 8.8 15.2 15 15 15
y4 (1+) 9.6 6.8 8.5 10.4 7.2 14.4 14.2 9.9 16.7 15 15 15
y5 (1+) 9.1 7.2 9.7 9.2 6.3 14 12.9 9.6 17 15 15 15
y6 (1+) 8.5 5.8 6.5 10.3 5.7 13 13.4 8.1 14.5 15 15 15
sum 7.7 6.2 7.1 9.7 5.6 12.3 12.4 8.4 14.2 15 15 15

Additional Resources and Comments


Assay Details for CPTAC-1780 Collapse assay details

Data source: Panorama

Official Gene Symbol
FGFR1
Peptide Modified Sequence
DLVSC[+57.0]AY[+80.0]QVAR
Modification Type
Carbamidomethyl (C), Phospho (Y)
Protein - Site of Modification
603, 605
Peptide - Site of Modification
5, 7
Peptide Start
599
Peptide End
609
CPTAC ID
CPTAC-1780
Peptide Molecular Mass
1,360.5847
Species
Homo sapiens (Human)
Assay Type
Direct PRM
Matrix
E.coli lysate
Submitting Laboratory
Johns Hopkins University / Pandey
Submitting Lab PI
Akhilesh Pandey

Assay Parameters Collapse assay parameters Test button response curves

Data source: Panorama

Instrument
Orbitrap Fusion Lumos
Internal Standard
100fmol
Peptide Standard Purity
Crude (~60%)
Peptide Standard Label Type
13C and 15N at C-terminus R
LC
Easy nLC 1200 System
Column Packing
C18 2um 100A
Column Dimensions
75um i.d. x 50cm
Flow Rate
300 nl/min

Chromatograms

Data source: Panorama


Response Curves

Data source: Panorama

Retrieving Data

Loader

Repeatability

Data source: Panorama

  Average intra-assay CV
(within day CV)
Average inter-assay CV
(between day CV)
Total CV
equation
n=
Fragment ion / Transition Low Med High Low Med High Low Med High Low Med High
y9 (1+) 80 21.8 5.3 85.2 26.2 5.4 116.9 34.1 7.6 14 15 15
y8 (1+) 22.8 4.7 2.5 27.6 6.7 2.4 35.8 8.2 3.5 15 15 15
y7 (1+) 35.5 11 4.2 50.5 21.1 5 61.7 23.8 6.5 15 15 15
y6 (1+) 33.1 7.6 1.6 44.5 13.3 3.6 55.5 15.3 3.9 15 15 15
y5 (1+) 54.4 12.1 5 55 21.2 4.3 77.4 24.4 6.6 14 15 15
b2 (1+) 23.5 3.4 3 46.3 16.6 4.5 51.9 16.9 5.4 15 15 15
b3 (1+) 86.8 26.9 5.1 102.5 49.5 7.4 134.3 56.3 9 14 15 15
sum 25.7 3.9 1.7 37.7 12.8 1.9 45.6 13.4 2.5 15 15 15

Additional Resources and Comments