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Overview Data source: UniProt

Official Gene Symbol Other Aliases
ICOSLG B7H2,B7RP1,ICOSL,KIAA0653
Sequence Length (AA) Molecular Weight (Da)
302 33349
Protein Name
ICOS ligand
Sources
UniProt
PhosphoSitePlus ®
GeneCards
Human Protein Atlas

Protein Sequence hover to view complete sequence

10 20 30 40 50
MRLGSPGLLF LLFSSLRADT QEKEVRAMVG SDVELSCACP EGSRFDLNDV
60 70 80 90 100
YVYWQTSESK TVVTYHIPQN SSLENVDSRY RNRALMSPAG MLRGDFSLRL
110 120 130 140 150
FNVTPQDEQK FHCLVLSQSL GFQEVLSVEV TLHVAANFSV PVVSAPHSPS
160 170 180 190 200
QDELTFTCTS INGYPRPNVY WINKTDNSLL DQALQNDTVF LNMRGLYDVV
210 220 230 240 250
SVLRIARTPS VNIGCCIENV LLQQNLTVGS QTGNDIGERD KITENPVSTG
260 270 280 290 300
EKNAATWSIL AVLCLLVVVA VAIGWVCRDR CLQHSYAGAW AVSPETELTG
302
HV

Data source: UniProt


Position of Targeted Peptide Analytes Relative to SNPs, Isoforms, and PTMs

Uniprot Database Entry PhosphoSitePlus ®

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Phosphorylation Acetylation Ubiquitylation Other

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Assay Details for CPTAC-2600 Collapse assay details

Data source: Panorama

Official Gene Symbol
ICOSLG
Peptide Modified Sequence
TDNSLLDQALQN[+1.0]DTVFLNM[+16.0]R
Modification Type
Deamidated (N), Oxidation (M)
Protein - Site of Modification
186, 193
Peptide - Site of Modification
12, 19
Peptide Start
175
Peptide End
194
CPTAC ID
CPTAC-2600
Peptide Molecular Mass
2,324.0954
Species
Homo sapiens (Human)
Assay Type
Direct MRM
Matrix
Human ovarian tumor tissue digest
Submitting Laboratory
Johns Hopkins University
Submitting Lab PI
Daniel Chan, Hui Zhang, Zhen Zhang

Assay Parameters Collapse assay parameters

Data source: Panorama

Instrument
TSQ Vantage
Internal Standard
Stable isotope-labeled peptides
Peptide Standard Purity
Crude (~60%)
Peptide Standard Label Type
13C and 15N at C-terminus R
LC
Accela 1250 Quaternary Low Pump
Column Packing
C18, 3 µm, 300 Å
Column Dimensions
1.0 mm I.D. x 15 cm
Flow Rate
50 µL/min

Assay Multiplexing Expand assay panel

Johns Hopkins University-I


Chromatograms

Data source: Panorama


Response Curves

Data source: Panorama

Retrieving Data

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Repeatability

Data source: Panorama

  Average intra-assay CV
(within day CV)
Average inter-assay CV
(between day CV)
Total CV
equation
n=
Fragment ion / Transition Low Med High Low Med High Low Med High Low Med High
y6 (1+) 37.8 20.1 20.6 29.9 20.3 23.5 48.2 28.6 31.3 15 15 15
y5 (1+) 18.1 10.4 7.4 20.7 16.3 8.4 27.5 19.3 11.2 15 15 15
y4 (1+) 31.8 13.1 14.3 28.7 14.8 13.9 42.8 19.8 19.9 15 15 15
sum 14.2 9.9 6.2 16.4 15.5 8.2 21.7 18.4 10.3 15 15 15

Additional Resources and Comments