| Official Gene Symbol | Other Aliases |
|---|---|
| RB1 | N/A |
| Sequence Length (AA) | Molecular Weight (Da) |
|---|---|
| 928 | 106159 |
| Protein Name |
|---|
| Retinoblastoma-associated protein |
| Sources | |
|---|---|
|
UniProt PhosphoSitePlus ® GeneCards |
Human Protein Atlas |
| 10 | 20 | 30 | 40 | 50 |
| MPPKTPRKTA | ATAAAAAAEP | PAPPPPPPPE | EDPEQDSGPE | DLPLVRLEFE |
| 60 | 70 | 80 | 90 | 100 |
| ETEEPDFTAL | CQKLKIPDHV | RERAWLTWEK | VSSVDGVLGG | YIQKKKELWG |
| 110 | 120 | 130 | 140 | 150 |
| ICIFIAAVDL | DEMSFTFTEL | QKNIEISVHK | FFNLLKEIDT | STKVDNAMSR |
| 160 | 170 | 180 | 190 | 200 |
| LLKKYDVLFA | LFSKLERTCE | LIYLTQPSSS | ISTEINSALV | LKVSWITFLL |
| 210 | 220 | 230 | 240 | 250 |
| AKGEVLQMED | DLVISFQLML | CVLDYFIKLS | PPMLLKEPYK | TAVIPINGSP |
| 260 | 270 | 280 | 290 | 300 |
| RTPRRGQNRS | ARIAKQLEND | TRIIEVLCKE | HECNIDEVKN | VYFKNFIPFM |
| 310 | 320 | 330 | 340 | 350 |
| NSLGLVTSNG | LPEVENLSKR | YEEIYLKNKD | LDARLFLDHD | KTLQTDSIDS |
| 360 | 370 | 380 | 390 | 400 |
| FETQRTPRKS | NLDEEVNVIP | PHTPVRTVMN | TIQQLMMILN | SASDQPSENL |
| 410 | 420 | 430 | 440 | 450 |
| ISYFNNCTVN | PKESILKRVK | DIGYIFKEKF | AKAVGQGCVE | IGSQRYKLGV |
| 460 | 470 | 480 | 490 | 500 |
| RLYYRVMESM | LKSEEERLSI | QNFSKLLNDN | IFHMSLLACA | LEVVMATYSR |
| 510 | 520 | 530 | 540 | 550 |
| STSQNLDSGT | DLSFPWILNV | LNLKAFDFYK | VIESFIKAEG | NLTREMIKHL |
| 560 | 570 | 580 | 590 | 600 |
| ERCEHRIMES | LAWLSDSPLF | DLIKQSKDRE | GPTDHLESAC | PLNLPLQNNH |
| 610 | 620 | 630 | 640 | 650 |
| TAADMYLSPV | RSPKKKGSTT | RVNSTANAET | QATSAFQTQK | PLKSTSLSLF |
| 660 | 670 | 680 | 690 | 700 |
| YKKVYRLAYL | RLNTLCERLL | SEHPELEHII | WTLFQHTLQN | EYELMRDRHL |
| 710 | 720 | 730 | 740 | 750 |
| DQIMMCSMYG | ICKVKNIDLK | FKIIVTAYKD | LPHAVQETFK | RVLIKEEEYD |
| 760 | 770 | 780 | 790 | 800 |
| SIIVFYNSVF | MQRLKTNILQ | YASTRPPTLS | PIPHIPRSPY | KFPSSPLRIP |
| 810 | 820 | 830 | 840 | 850 |
| GGNIYISPLK | SPYKISEGLP | TPTKMTPRSR | ILVSIGESFG | TSEKFQKINQ |
| 860 | 870 | 880 | 890 | 900 |
| MVCNSDRVLK | RSAEGSNPPK | PLKKLRFDIE | GSDEADGSKH | LPGESKFQQK |
| 910 | 920 | 928 | ||
| LAEMTSTRTR | MQKQKMNDSM | DTSNKEEK |
Data source: UniProt
Uniprot Database Entry PhosphoSitePlus ®
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Data source: Panorama
View Details (opens in a new window)
Abelin, et al. Mol Cell Proteomics. 2016 May;15(5):1622-41. doi: 10.1074/mcp.M116.058354. Epub 2016 Feb 24. PMID:26912667
Data source: Panorama
Broad Institute-Biologist curated set of targets across a number of important cancer pathways
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y8 (1+) | 10.5 | 4.9 | 4.9 | 11.9 | 8.7 | 13.3 | 15.9 | 10 | 14.2 | 15 | 15 | 15 |
| y7 (1+) | 5.2 | 2.9 | 3.3 | 7.6 | 4.1 | 8.5 | 9.2 | 5 | 9.1 | 15 | 15 | 15 |
| y7-98 (1+) | 5.7 | 4.7 | 7.4 | 6.3 | 7.6 | 13.5 | 8.5 | 8.9 | 15.4 | 15 | 15 | 15 |
| sum | 4.7 | 2.9 | 3.6 | 5.9 | 4.7 | 9.7 | 7.5 | 5.5 | 10.3 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Kennedy JJ, Yan P, Zhao L, Ivey RG, Voytovich U, Moore HD, Lin C, Pogosova-Agadjanyan EL, Stirewalt DL, Reding KW, Whiteaker JR, Paulovich AG. Immobilized metal affinity chromatography coupled to multiple reaction monitoring enables reproducible quantification of phospho-signaling. Molecular and Cellular Proteomics. mcp.O115.054940
Data source: Panorama
Broad Institute-Biologist curated set of targets across a number of important cancer pathways
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y10 (2+) | 51.1 | 30.6 | 47.9 | 41.2 | 25.3 | 34.9 | 65.6 | 39.7 | 59.3 | 15 | 24 | 15 |
| y11 (2+) | 50.3 | 15.7 | 16.4 | 40.4 | 12.9 | 17.1 | 64.5 | 20.3 | 23.7 | 15 | 24 | 15 |
| y6 (1+) | 46.2 | 33.1 | 45.2 | 48.9 | 36.1 | 73 | 67.3 | 49 | 85.9 | 15 | 24 | 15 |
| sum | 40.5 | 15.3 | 21 | 36.9 | 11.9 | 20.8 | 54.8 | 19.4 | 29.6 | 15 | 24 | 15 |
Data source: Panorama
View Details (opens in a new window)
A Multiplexed Mass Spectrometry-Based Assay for Robust Quantification of Phosphosignaling in Response to DNA Damage. Whiteaker JR, Zhao L, Saul R, Kaczmarczyk JA, Schoenherr RM, Moore HD, Jones-Weinert C, Ivey RG, Lin C, Hiltke T, Reding KW, Whiteley G, Wang P, Paulovich AG. Radiat Res. 2018 Feb 23. doi: 10.1667/RR14963.1. [Epub ahead of print]
Data source: Panorama
Broad Institute-Biologist curated set of targets across a number of important cancer pathways
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y3 (1+) | 14.9 | 12.4 | 10.3 | 18.4 | 14.3 | 12.5 | 23.7 | 18.9 | 16.2 | 15 | 15 | 15 |
| y6 (1+) | 24 | 12.1 | 5.8 | 22.2 | 13 | 7.3 | 32.7 | 17.8 | 9.3 | 15 | 15 | 15 |
| y5 (1+) | 26.4 | 18.6 | 16.4 | 36.5 | 18.1 | 18.9 | 45 | 26 | 25 | 15 | 15 | 15 |
| sum | 10 | 11 | 6 | 13.2 | 9.8 | 8.6 | 16.6 | 14.7 | 10.5 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
A Multiplexed Mass Spectrometry-Based Assay for Robust Quantification of Phosphosignaling in Response to DNA Damage. Whiteaker JR, Zhao L, Saul R, Kaczmarczyk JA, Schoenherr RM, Moore HD, Jones-Weinert C, Ivey RG, Lin C, Hiltke T, Reding KW, Whiteley G, Wang P, Paulovich AG. Radiat Res. 2018 Feb 23. doi: 10.1667/RR14963.1. [Epub ahead of print]
Data source: Panorama
Broad Institute-Biologist curated set of targets across a number of important cancer pathways
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y5 (1+) | 63.2 | 45.5 | 54.1 | 91.1 | 51.7 | 76.7 | 110.9 | 68.9 | 93.9 | 15 | 15 | 15 |
| y6 (1+) | 55.9 | 12.9 | 26.5 | 52.8 | 21.5 | 23.7 | 76.9 | 25.1 | 35.6 | 15 | 15 | 15 |
| y10 (1+) | 31.5 | 48.1 | 5.9 | 47 | 88.4 | 13.1 | 56.6 | 100.6 | 14.4 | 15 | 15 | 15 |
| y10 (2+) | 26.4 | 38.8 | 27.1 | 40 | 37.6 | 32.7 | 47.9 | 54 | 42.5 | 15 | 15 | 15 |
| y3 (1+) | 37.8 | 30.1 | 12.6 | 53.1 | 36.4 | 21.6 | 65.2 | 47.2 | 25 | 15 | 15 | 15 |
| sum | 19.1 | 12.7 | 9.3 | 33.6 | 18.1 | 12.3 | 38.6 | 22.1 | 15.4 | 15 | 15 | 15 |
Data source: Panorama
View Details (opens in a new window)
Kennedy JJ, Yan P, Zhao L, Ivey RG, Voytovich U, Moore HD, Lin C, Pogosova-Agadjanyan EL, Stirewalt DL, Reding KW, Whiteaker JR, Paulovich AG. Immobilized metal affinity chromatography coupled to multiple reaction monitoring enables reproducible quantification of phospho-signaling. Molecular and Cellular Proteomics. mcp.O115.054940
Data source: Panorama
Broad Institute-Biologist curated set of targets across a number of important cancer pathways
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y7 (2+) | 19.7 | 5.9 | 9.9 | 27.5 | 6.8 | 9.9 | 33.8 | 9 | 14 | 15 | 24 | 15 |
| y6 (1+) | 18.7 | 9.4 | 9.9 | 32.8 | 12.6 | 13.3 | 37.8 | 15.7 | 16.6 | 15 | 24 | 15 |
| y7 (1+) | 15.6 | 6.5 | 4.8 | 27.1 | 8.5 | 5.8 | 31.3 | 10.7 | 7.5 | 15 | 24 | 15 |
| sum | 15.6 | 5.7 | 4.8 | 26.5 | 7.8 | 5.8 | 30.8 | 9.7 | 7.5 | 15 | 24 | 15 |
Data source: Panorama
Data source: Panorama
Broad Institute-Biologist curated set of targets across a number of important cancer pathways
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y4 (1+) | 43.6 | 26.7 | 10.8 | 44.5 | 26.2 | 11.4 | 62.3 | 37.4 | 15.7 | 15 | 15 | 15 |
| b6 (1+) | 36.7 | 29.9 | 18.8 | 43.8 | 28.5 | 19.6 | 57.1 | 41.3 | 27.2 | 15 | 15 | 15 |
| b5 (1+) | 24.3 | 10.6 | 11.2 | 23.8 | 12.8 | 10 | 34 | 16.6 | 15 | 15 | 15 | 15 |
| sum | 20.3 | 12.5 | 8.7 | 22.2 | 13.4 | 7.6 | 30.1 | 18.3 | 11.6 | 15 | 15 | 15 |
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