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Please include the following statement when referencing the CPTAC Assay Portal
We would like to acknowledge the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) Assay Portal (assays.cancer.gov) for developing assays and establishing criteria for the assays described in this publication.

CDK11A

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Available Assays

Overview Data source: UniProt

Official Gene Symbol Other Aliases
CDK11A CDC2L2, CDC2L3, PITSLREB
Sequence Length (AA) Molecular Weight (Da)
783 91362
Protein Name
Cyclin-dependent kinase 11A
Sources
UniProt
PhosphoSitePlus ®
GeneCards 		Human Protein Atlas

Protein Sequence hover to view complete sequence

10 20 30 40 50
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE
60 70 80 90 100
GELRDHCMEI TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKVHHR
110 120 130 140 150
KDEKRKEKWK HARVKEREHE RRKRHREEQD KARREWERQK RREMAREHSR
160 170 180 190 200
RERDRLEQLE RKRERERKMR EQQKEQREQK ERERRAEERR KEREARREVS
210 220 230 240 250
AHHRTMREDY SDKVKASHWS RSPPRPPRER FELGDGRKPG EARPAPAQKP
260 270 280 290 300
AQLKEEKMEE RDLLSDLQDI SDSERKTSSA ESSSAESGSG SEEEEEEEEE
310 320 330 340 350
EEEEGSTSEE SEEEEEEEEE EEEETGSNSE EASEQSAEEV SEEEMSEDEE
360 370 380 390 400
RENENHLLVV PESRFDRDSG ESEEAEEEVG EGTPQSSALT EGDYVPDSPA
410 420 430 440 450
LLPIELKQEL PKYLPALQGC RSVEEFQCLN RIEEGTYGVV YRAKDKKTDE
460 470 480 490 500
IVALKRLKME KEKEGFPITS LREINTILKA QHPNIVTVRE IVVGSNMDKI
510 520 530 540 550
YIVMNYVEHD LKSLMETMKQ PFLPGEVKTL MIQLLRGVKH LHDNWILHRD
560 570 580 590 600
LKTSNLLLSH AGILKVGDFG LAREYGSPLK AYTPVVVTQW YRAPELLLGA
610 620 630 640 650
KEYSTAVDMW SVGCIFGELL TQKPLFPGNS EIDQINKVFK ELGTPSEKIW
660 670 680 690 700
PGYSELPVVK KMTFSEHPYN NLRKRFGALL SDQGFDLMNK FLTYFPGRRI
710 720 730 740 750
SAEDGLKHEY FRETPLPIDP SMFPTWPAKS EQQRVKRGTS PRPPEGGLGY
760 770 780 783
SQLGDDDLKE TGFHLTTTNQ GASAAGPGFS LKF

Data source: UniProt

Protein Map Collapse protein map

Position of Targeted Peptide Analytes Relative to SNPs, Isoforms, and PTMs

Uniprot Database Entry PhosphoSitePlus ®

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Phosphorylation Acetylation Ubiquitylation Other

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Assay Details for non-CPTAC-5631 Collapse assay details

Data source: Panorama

Official Gene Symbol
CDK11A
Peptide Sequence
AYTPVVVTQWYR
Modification Type
unmodified
Protein - Site of Modification
N/A
Peptide - Site of Modification
3
Peptide Start
581
Peptide End
592
CPTAC ID
non-CPTAC-5631
Peptide Molecular Mass
1,481.7667
Species
Homo sapiens (Human)
Assay Type
Direct PRM
Matrix
SUM159 tryptic digest
Submitting Laboratory
Washington University in St. Louis
Submitting Lab PI
Reid Townsend

Assay Parameters Collapse assay parameters

Data source: Panorama

Instrument
Q-Exactive
Internal Standard
25fmol
Peptide Standard Purity
>95%
Peptide Standard Label Type
13C and 15N at C-terminus R
LC
EASY-nLC 1000
Column Packing
C18
Column Dimensions
75 µm x 50 cm
Flow Rate
300nL/min

Chromatograms

Data source: Panorama

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Response Curves

Data source: Panorama

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Retrieving Data

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Repeatability

Data source: Panorama

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  Average intra-assay CV
(within day CV)		 Average inter-assay CV
(between day CV)		 Total CV
equation		 n=
Fragment ion / Transition Low Med High Low Med High Low Med High Low Med High
y7 (1+) 1.6 1.1 3.2 1.5 1.7 3.3 2.2 2 4.6 15 15 15
y6 (1+) 1.4 1.4 4.1 1.6 1.5 5.1 2.1 2.1 6.5 15 15 15
y9 (1+) 2.6 2.1 4 2.4 2.6 4.7 3.5 3.3 6.2 15 15 15
sum 1.5 1.4 2.9 1.5 1.8 2.9 2.1 2.3 4.1 15 15 15

Additional Resources and Comments

Resources
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View Peptide in Panorama
View Protein in Panorama
Comments

Assay Details for non-CPTAC-2978 Collapse assay details

Data source: Panorama

Official Gene Symbol
CDK11A
Peptide Sequence
IYIVMNYVEHDLK
Modification Type
unmodified
Protein - Site of Modification
N/A
Peptide - Site of Modification
N/A
Peptide Start
500
Peptide End
512
CPTAC ID
non-CPTAC-2978
Peptide Molecular Mass
1,635.8331
Species
Homo Sapiens
Assay Type
Direct PRM
Matrix
Tumor Digest
Submitting Laboratory
Washington University in St. Louis
Submitting Lab PI
Reid Townsend

Assay Parameters Collapse assay parameters

Data source: Panorama

Instrument
ThermoFisher, Q-Exactive
Internal Standard
25 fmol on column
Peptide Standard Purity
>95%
Peptide Standard Label Type
13C and 15N at C-terminus K
LC
Easy-nLC 1000 Thermo Scientific
Column Packing
C18
Column Dimensions
75 µm x 50 cm
Flow Rate
300 nL/min

Chromatograms

Data source: Panorama

view larger image
view larger image
view larger image

Response Curves

Data source: Panorama

view larger image
view larger image
view larger image

Retrieving Data

Loader

Repeatability

Data source: Panorama

view larger image
  Average intra-assay CV
(within day CV)		 Average inter-assay CV
(between day CV)		 Total CV
equation		 n=
Fragment ion / Transition Low Med High Low Med High Low Med High Low Med High
y9 (1+) 11.8 10.2 11.2 11.4 14.6 12.3 16.4 17.8 16.6 15 15 15
y6 (1+) 15.8 12.7 12.9 14.2 14.4 13.2 21.2 19.2 18.5 15 15 15
y5 (1+) 9.7 10.1 10.9 10.6 15 11.6 14.4 18.1 15.9 15 15 15
sum 11.4 10.6 11 10.4 14.4 11.9 15.4 17.9 16.2 15 15 15

Additional Resources and Comments

Resources
Download SOPs
View Peptide in Panorama
View Protein in Panorama
Comments