CNDP1, CPTAC-1484 - CPTAC Assay Portal | Office of Cancer Clinical Proteomics Research

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We would like to acknowledge the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC) Assay Portal (assays.cancer.gov) for developing assays and establishing criteria for the assays described in this publication.

Overview Data source: UniProt

Official Gene Symbol	Other Aliases
CNDP1	CN1, CPGL2

Sequence Length (AA)	Molecular Weight (Da)
507	56706

Protein Name
Beta-Ala-His dipeptidase

Sources
UniProt PhosphoSitePlus ® GeneCards	Human Protein Atlas

Protein Sequence hover to view complete sequence

10	20	30	40	50
MDPKLGRMAA	SLLAVLLLLL	ERGMFSSPSP	PPALLEKVFQ	YIDLHQDEFV
60	70	80	90	100
QTLKEWVAIE	SDSVQPVPRF	RQELFRMMAV	AADTLQRLGA	RVASVDMGPQ
110	120	130	140	150
QLPDGQSLPI	PPIILAELGS	DPTKGTVCFY	GHLDVQPADR	GDGWLTDPYV
160	170	180	190	200
LTEVDGKLYG	RGATDNKGPV	LAWINAVSAF	RALEQDLPVN	IKFIIEGMEE
210	220	230	240	250
AGSVALEELV	EKEKDRFFSG	VDYIVISDNL	WISQRKPAIT	YGTRGNSYFM
260	270	280	290	300
VEVKCRDQDF	HSGTFGGILH	EPMADLVALL	GSLVDSSGHI	LVPGIYDEVV
310	320	330	340	350
PLTEEEINTY	KAIHLDLEEY	RNSSRVEKFL	FDTKEEILMH	LWRYPSLSIH
360	370	380	390	400
GIEGAFDEPG	TKTVIPGRVI	GKFSIRLVPH	MNVSAVEKQV	TRHLEDVFSK
410	420	430	440	450
RNSSNKMVVS	MTLGLHPWIA	NIDDTQYLAA	KRAIRTVFGT	EPDMIRDGST
460	470	480	490	500
IPIAKMFQEI	VHKSVVLIPL	GAVDDGEHSQ	NEKINRWNYI	EGTKLFAAFF
507
LEMAQLH

Data source: UniProt

Protein Map Collapse protein map

Position of Targeted Peptide Analytes Relative to SNPs, Isoforms, and PTMs

Uniprot Database Entry PhosphoSitePlus ®

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Assay Details for CPTAC-1484 Collapse assay details

Data source: Panorama

Official Gene Symbol: CNDP1
Peptide Modified Sequence: LVPHM[+16.0]N[+1.0]VSAVEK
Modification Type: Oxidation (M), Deamidated (N)
Protein - Site of Modification: 381, 382
Peptide - Site of Modification: 5, 6
Peptide Start: 377
Peptide End: 388

CPTAC ID: CPTAC-1484
Peptide Molecular Mass: 1,339.6806
Species: Homo sapiens (Human)
Assay Type: Direct MRM
Matrix: Human ovarian tumor tissue digest
Submitting Laboratory: Johns Hopkins University
Submitting Lab PI: Daniel Chan, Hui Zhang, Zhen Zhang

Assay Parameters Collapse assay parameters

Data source: Panorama

Instrument: TSQ Vantage
Internal Standard: Stable isotope-labeled peptides
Peptide Standard Purity: Crude (~60%)
Peptide Standard Label Type: 13C and 15N at C-terminus K

LC: Accela 1250 Quaternary Low Pump
Column Packing: C18, 3 µm, 300 Å
Column Dimensions: 1.0 mm I.D. x 15 cm
Flow Rate: 50 µL/min

Assay Multiplexing Expand assay panel

Johns Hopkins University-E

CPTAC-1479: F3. N[+1.0]NTFLSLR	CPTAC-1480: CADM1. TDN[+1.0]GTYR	CPTAC-1481: CD164. TVTTSGTTN[+1.0]NTVTPTSQPVR
CPTAC-1483: CHST3. N[+1.0]SSEQFEK	CPTAC-1484: CNDP1. LVPHM[+16.0]N[+1.0]VSAVEK	CPTAC-1485: COL6A3. QEVLSHISN[+1.0]M[+16.0]SYIGGTNQTGK
CPTAC-1486: CPE. GN[+1.0]ETIVNLIHSTR	CPTAC-1488: DPY19L4. GVYELTHNN[+1.0]K	CPTAC-1489: ENTPD2. LLN[+1.0]LTNPEASTSVLM[+16.0]AVTHTLTQYPFDFR
CPTAC-1490: BPIFB1. DHN[+1.0]ATSILQQLPLLSAM[+16.0]R	CPTAC-1491: FOLH1. VPYNVGPGFTGN[+1.0]FSTQK	CPTAC-1492: ITGA9. N[+1.0]QTVFER
CPTAC-1493: GGT7. TAN[+1.0]HSAPSLENSVQPGK	CPTAC-1494: LAMP2. VASVININPN[+1.0]TTHSTGSC[+57.0]R	CPTAC-1495: LRIG1. LHELVLSFNN[+1.0]LTR
CPTAC-1496: MET. FINFFVGNTIN[+1.0]SSYFPDHPLHSISVR	CPTAC-1497: MUC2. GDHN[+1.0]DSYALLGELAPC[+57.0]GSTDK	CPTAC-1498: MUC5B. YSFEGSC[+57.0]EYILAQDYC[+57.0]GDN[+1.0]TTHGTFR
CPTAC-1499: PIGT. TYAIYDLLDTAM[+16.0]IN[+1.0]NSR	CPTAC-1500: PLOD1. EQIN[+1.0]ITLDHR	CPTAC-1501: PLOD3. EQYIHEN[+1.0]YSR
CPTAC-1503: ALCAM. TIIC[+57.0]HVEGFPKPAIQWTITGSGSVIN[+1.0]QTEESPYINGR	CPTAC-1504: PLXNB2. LSHDAN[+1.0]ETLPLHLYVK	CPTAC-1506: POFUT1. EGNPFGPFWDQFHVSFN[+1.0]K
CPTAC-1507: SCGB2A1. QC[+57.0]FLN[+1.0]QSHR	CPTAC-1508: SERPIND1. DFVN[+1.0]ASSK	CPTAC-1509: SUN1. N[+1.0]VTHHVSVTK
CPTAC-1510: TACSTD2. HRPTAGAFN[+1.0]HSDLDAELR	CPTAC-1511: THY1. DEGTYTC[+57.0]ALHHSGHSPPISSQN[+1.0]VTVLR	CPTAC-1512: TMX4. VQPM[+16.0]TASN[+1.0]WTLVM[+16.0]EGEWM[+16.0]LK
CPTAC-1513: TWSG1. N[+1.0]YSDTPPTSK	CPTAC-1514: PPT1. FLN[+1.0]DSIVDPVDSEWFGFYR

Chromatograms

Data source: Panorama

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Response Curves

Data source: Panorama

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Retrieving Data

Repeatability

Data source: Panorama

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	Average intra-assay CV (within day CV)			Average inter-assay CV (between day CV)			Total CV			n=
Fragment ion / Transition	Low	Med	High	Low	Med	High	Low	Med	High	Low	Med	High
y8 (1+)	10	5.6	5.2	11.6	7.5	6.5	15.3	9.4	8.3	15	15	15
y10 (2+)	5	3.4	3.6	7.1	4.2	3.9	8.7	5.4	5.3	15	15	15
y9 (2+)	9.8	4.5	8.6	13.9	4.3	9	17	6.2	12.4	15	15	15
sum	5.2	2.5	2.6	7.7	3	2.8	9.3	3.9	3.8	15	15	15

CNDP1

Overview Data source: UniProt

Protein Sequence hover to view complete sequence

Protein Map Collapse protein map

Position of Targeted Peptide Analytes Relative to SNPs, Isoforms, and PTMs

Assay Details for CPTAC-1484 Collapse assay details

Assay Parameters Collapse assay parameters

Assay Multiplexing Expand assay panel

Chromatograms

Response Curves

Repeatability

Additional Resources and Comments

Comments

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CNDP1

Overview Data source: UniProt

Protein Sequence hover to view complete sequence

Protein Map Collapse protein map

Position of Targeted Peptide Analytes Relative to SNPs, Isoforms, and PTMs

Assay Details for CPTAC-1484 Collapse assay details

Assay Parameters Collapse assay parameters

Assay Multiplexing Expand assay panel

Chromatograms

Response Curves

Repeatability

Additional Resources and Comments

Comments